Pyridone 6
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MedKoo CAT#: 406781

CAS#: 457081-03-7

Description: Pyridone 6, also known CMP 6 or JAK Inhibitor I, is a pan-Janus-activated kinase inhibitor, Pyridone 6 interferes with JAK kinase activity by interacting within the ATP-binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively. Pyridone 6 suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression. Pyridone 6 induces growth inhibition of multiple myeloma cells.


Price and Availability

Size
Price

50mg
USD 450
500mg
USD 1950
Size
Price

100mg
USD 850
1g
USD 3450
Size
Price

200mg
USD 1250
2g
USD 5650

Pyridone 6, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406781
Name: Pyridone 6
CAS#: 457081-03-7
Chemical Formula: C18H16FN3O
Exact Mass: 309.1277
Molecular Weight: 309.3444
Elemental Analysis: C, 69.89; H, 5.21; F, 6.14; N, 13.58; O, 5.17


Synonym: Pyridone 6; Pyridone-6; Pyridone6; CMP 6; JAK Inhibitor I; Janus-Associated Kinase Inhibitor I.

IUPAC/Chemical Name: 2-(1,1-dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one

InChi Key: VNDWQCSOSCCWIP-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)

SMILES Code: O=C1NC=CC2=C1C3=CC(F)=CC=C3C4=C2N=C(C(C)(C)C)N4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Nakagawa R, Yoshida H, Asakawa M, Tamiya T, Inoue N, Morita R, Inoue H, Nakao
A, Yoshimura A. Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin
inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17. J
Immunol. 2011 Nov 1;187(9):4611-20. doi: 10.4049/jimmunol.1100649. Epub 2011 Sep
28. PubMed PMID: 21957150.

2: Matsunaga Y, Inoue H, Fukuyama S, Yoshida H, Moriwaki A, Matsumoto T,
Matsumoto K, Asai Y, Kubo M, Yoshimura A, Nakanishi Y. Effects of a Janus kinase
inhibitor, pyridone 6, on airway responses in a murine model of asthma. Biochem
Biophys Res Commun. 2011 Jan 7;404(1):261-7. doi: 10.1016/j.bbrc.2010.11.104.
Epub 2010 Nov 25. PubMed PMID: 21111712.

3: Kwak HB, Kim HS, Lee MS, Kim KJ, Choi EY, Choi MK, Kim JJ, Cho HJ, Kim JW, Bae
JM, Kim YK, Park BH, Ha H, Chun CH, Oh J. Pyridone 6, a pan-Janus-activated
kinase inhibitor, suppresses osteoclast formation and bone resorption through
down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand
(RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1
expression. Biol Pharm Bull. 2009 Jan;32(1):45-50. PubMed PMID: 19122279.

4: Pedranzini L, Dechow T, Berishaj M, Comenzo R, Zhou P, Azare J, Bornmann W,
Bromberg J. Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth
inhibition of multiple myeloma cells. Cancer Res. 2006 Oct 1;66(19):9714-21.
PubMed PMID: 17018630.