Torin-1 | CAS#1222998-36-8 | mTOR inhibitor

Torin-1
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406735

CAS#: 1222998-36-8

Description: Torin-1 is a potent and selective mTOR inhibitor. The apoptosis-inducing mTOR inhibitor Torin-1 hindered growth, motility, invasion, and survival of CoCSCs in vitro, and suppressed tumor growth in vivo with a concomitant reduction in vessel formation. Torin-1 also affected the expression of markers for cell proliferation, angio-/lympho-genesis, and stemness in vivo, including Ki67, DLL1, DLL4, Notch, Lgr5, and CD44. Importantly, Torin-1 did not affect the survival of normal colon stem cells in vivo, suggesting its selectivity towards cancer cells.

Chemical Structure

Torin-1

CAS# 1222998-36-8

Instruction

Theoretical Analysis

MedKoo Cat#: 406735
Name: Torin-1
CAS#: 1222998-36-8
Chemical Formula: C35H28F3N5O2
Exact Mass: 607.22
Molecular Weight: 607.637
Elemental Analysis: C, 69.18; H, 4.64; F, 9.38; N, 11.53; O, 5.27

Price and Availability

Size	Price	Availability	Quantity
50mg	USD 750
100mg	USD 1250
200mg	USD 2150
500mg	USD 2950
1g	USD 3750
2g	USD 5250
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Torin-1; Torin1; Torin 1.

IUPAC/Chemical Name: 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one

InChi Key: AKCRNFFTGXBONI-UHFFFAOYSA-N

InChi Code: InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3

SMILES Code: O=C1N(C2=CC=C(N3CCN(C(CC)=O)CC3)C(C(F)(F)F)=C2)C4=C(C=NC5=CC=C(C6=CC7=CC=CC=C7N=C6)C=C54)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 607.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cheng NT, Guo A, Meng H. The protective role of autophagy in experimental
osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by
activating autophagy. BMC Musculoskelet Disord. 2016 Apr 6;17(1):150. doi:
10.1186/s12891-016-0995-x. PubMed PMID: 27052304; PubMed Central PMCID:
PMC4823842.

2: Vogel KR, Ainslie GR, Jansen EE, Salomons GS, Gibson KM. Torin 1 partially
corrects vigabatrin-induced mitochondrial increase in mouse. Ann Clin Transl
Neurol. 2015 Jun;2(6):699-706. doi: 10.1002/acn3.200. Epub 2015 Apr 17. PubMed
PMID: 26125044; PubMed Central PMCID: PMC4479529.

3: Francipane MG, Lagasse E. Selective targeting of human colon cancer stem-like
cells by the mTOR inhibitor Torin-1. Oncotarget. 2013 Nov;4(11):1948-62. PubMed
PMID: 24185040; PubMed Central PMCID: PMC3875761.

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