Sertraline HCl
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318692

CAS#: 79559-97-0 (HCl)

Description: Sertraline, also known as , is a selective serotonin uptake inhibitor that is used in the treatment of depression. Sertraline is primarily a serotonin reuptake inhibitor (SRI) with a binding affinity towards the serotonin transporter of Ki=2.8 nM or in that range. Sertraline is also a dopamine reuptake inhibitor, (<50 nmol/L). However, this is not considered a tight binding, and this action is only 10% of its potency as a monoamine reuptake inhibitor. It is a σ1 receptor agonist with 5% of its SRI potency, and an α1-adrenoreceptor antagonist with 1–10% of its SRI potency.


Chemical Structure

img
Sertraline HCl
CAS# 79559-97-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 318692
Name: Sertraline HCl
CAS#: 79559-97-0 (HCl)
Chemical Formula: C17H18Cl3N
Exact Mass: 0.00
Molecular Weight: 342.690
Elemental Analysis: C, 59.58; H, 5.29; Cl, 31.04; N, 4.09

Price and Availability

Size Price Availability Quantity
1g USD 110 Ready to ship
2g USD 180 Ready to ship
5g USD 360 2 weeks
10g USD 650 2 Weeks
25g USD 1050 2 Weeks
Bulk inquiry

Related CAS #: 79559-97-0 (HCl)   79617-96-2 (free base)  

Synonym: Sertraline Hydrochloride; Sertraline HCl; Sealdin; Adjuvin; Atruline; CP 51,974-1; Cp-51,974-1; CP 51,974; CP51,974; CP-51,974; Gladem; Tatig; Tresleen; Zoloft.

IUPAC/Chemical Name: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride

InChi Key: BLFQGGGGFNSJKA-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H

SMILES Code: CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 79617-96-2 (Sertraline free base) 79559-97-0 (Sertraline Hydrochloride)

Product Data:
Safety Data Sheet (SDS):
Biological target: Sertraline is selective for serotonin transporter (SERT) over the norepinephrine and dopamine transporters (IC50s = 520 and 720 nM, respectively).
In vitro activity: Sertraline shows a promise as a potential therapeutic option for breast cancer (BC), particularly in triple-negative BC, because of its ability to inhibit TCTP expression and enhance chemotherapeutic response. Sertraline treatment reduced translationally controlled tumor protein expression in BC cell lines, significantly impacting cell viability, clonogenicity, and migration. Sertraline sensitized triple-negative BC cell lines to cytotoxic chemotherapeutic drugs (doxorubicin and cisplatin). Reference: Adv Med Sci. 2023 Sep;68(2):227-237. https://pubmed.ncbi.nlm.nih.gov/37379765/
In vivo activity: Sertraline significantly ameliorated depression-like behaviors in Toxoplasma gondii-infected mice and inhibited T. gondii proliferation. Toxoplasma significantly inhibited the activation of microglia and decreased levels of pro-inflammatory cytokines by down-regulating tumor necrosis factor receptor 1/nuclear factor-kappa B signaling pathway, thereby ameliorating the depression-like behaviors induced by T. gondii infection. Reference: Parasite Immunol. 2021 Dec;43(12):e12893. https://pubmed.ncbi.nlm.nih.gov/34637545/

Preparing Stock Solutions

The following data is based on the product molecular weight 342.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Baldissera AB, Boia-Ferreira M, Basílio ABC, Resende JSS, Castro MAA, Chaim OM, Gremski LH, Veiga SS, Senff-Ribeiro A. Sertraline as a potential cancer therapeutic approach: Biological relevance of TCTP in breast cancer cell lines and tumors. Adv Med Sci. 2023 Sep;68(2):227-237. doi: 10.1016/j.advms.2023.06.001. Epub 2023 Jun 26. PMID: 37379765. 2. Matsushima Y, Terada K, Kamei C, Sugimoto Y. Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor. Eur J Pharmacol. 2019 Jun 15;853:129-135. doi: 10.1016/j.ejphar.2019.03.032. Epub 2019 Mar 19. PMID: 30902656. 3. Zhou S, Ye D, Xia H, Xu H, Tang W, Tang Q, Bi F. Sertraline inhibits stress-induced tumor growth through regulating CD8 + T cell-mediated anti-tumor immunity. Anticancer Drugs. 2022 Oct 1;33(9):935-942. doi: 10.1097/CAD.0000000000001383. Epub 2022 Sep 5. PMID: 36066403. 4. Lan HW, Lu YN, Zhao XD, Jin GN, Lu JM, Jin CH, Ma J, Jin X, Xu X, Piao LX. New role of sertraline against Toxoplasma gondii-induced depression-like behaviours in mice. Parasite Immunol. 2021 Dec;43(12):e12893. doi: 10.1111/pim.12893. Epub 2021 Oct 20. PMID: 34637545.
In vitro protocol: 1. Baldissera AB, Boia-Ferreira M, Basílio ABC, Resende JSS, Castro MAA, Chaim OM, Gremski LH, Veiga SS, Senff-Ribeiro A. Sertraline as a potential cancer therapeutic approach: Biological relevance of TCTP in breast cancer cell lines and tumors. Adv Med Sci. 2023 Sep;68(2):227-237. doi: 10.1016/j.advms.2023.06.001. Epub 2023 Jun 26. PMID: 37379765. 2. Matsushima Y, Terada K, Kamei C, Sugimoto Y. Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor. Eur J Pharmacol. 2019 Jun 15;853:129-135. doi: 10.1016/j.ejphar.2019.03.032. Epub 2019 Mar 19. PMID: 30902656.
In vivo protocol: 1. Zhou S, Ye D, Xia H, Xu H, Tang W, Tang Q, Bi F. Sertraline inhibits stress-induced tumor growth through regulating CD8 + T cell-mediated anti-tumor immunity. Anticancer Drugs. 2022 Oct 1;33(9):935-942. doi: 10.1097/CAD.0000000000001383. Epub 2022 Sep 5. PMID: 36066403. 2. Lan HW, Lu YN, Zhao XD, Jin GN, Lu JM, Jin CH, Ma J, Jin X, Xu X, Piao LX. New role of sertraline against Toxoplasma gondii-induced depression-like behaviours in mice. Parasite Immunol. 2021 Dec;43(12):e12893. doi: 10.1111/pim.12893. Epub 2021 Oct 20. PMID: 34637545.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Zhu Y, Yue J, Liu ZJ, Huang J, Bian TS, Wang JS, Zeng QQ. [Sertraline
hydrochloride combined with four-spot caressing for primary premature
ejaculation]. Zhonghua Nan Ke Xue. 2015 Dec;21(12):1116-20. Chinese. PubMed PMID:
26817306.


2: Dağ MS, Koruk İ, Aydınlı M, Çam H, Öztürk ZA, Kadayıfçı A. An unusual cause of
esophageal ulcer; sertraline hydrochloride. Turk J Gastroenterol. 2014 Dec;25
Suppl 1:250-1. doi: 10.5152/tjg.2014.4646. PubMed PMID: 25910325.


3: De Long NE, Gutgesell MK, Petrik JJ, Holloway AC. Fetal Exposure to Sertraline
Hydrochloride Impairs Pancreatic β-Cell Development. Endocrinology. 2015
Jun;156(6):1952-7. doi: 10.1210/en.2014-1779. Epub 2015 Mar 12. PubMed PMID:
25763636.


4: He Y, Zheng Y, Xu C, Yang H, Wang Z, Zhou L, Wan Y, Zheng D, Zhu J. Sertraline
hydrochloride treatment for patients with stable chronic obstructive pulmonary
disease complicated with depression: a randomized controlled trial. Clin Respir
J. 2016 May;10(3):318-25. doi: 10.1111/crj.12219. Epub 2014 Nov 9. PubMed PMID:
25308771.


5: Lamichhane K, Garcia SN, Huggett DB, Deangelis DL, La Point TW. Exposures to a
selective serotonin reuptake inhibitor (SSRI), sertraline hydrochloride, over
multiple generations: changes in life history traits in Ceriodaphnia dubia.
Ecotoxicol Environ Saf. 2014 Mar;101:124-30. doi: 10.1016/j.ecoenv.2013.11.026.
Epub 2014 Jan 11. PubMed PMID: 24507137.


6: Xu G, Jiang HW, Fang J, Wen H, Gu B, Liu J, Zhang LM, Ding Q, Zhang YF. An
improved dosage regimen of sertraline hydrochloride in the treatment for
premature ejaculation: an 8-week, single-blind, randomized controlled study
followed by a 4-week, open-label extension study. J Clin Pharm Ther. 2014
Feb;39(1):84-90. doi: 10.1111/jcpt.12115. Epub 2013 Dec 9. PubMed PMID: 24313633.


7: Vijaya R, Ruckmani K. In vitro and In vivo characterization of the transdermal
delivery of sertraline hydrochloride Films. Daru. 2011;19(6):424-32. PubMed PMID:
23008688; PubMed Central PMCID: PMC3436079.


8: Dermiş S, Cay HY. Electrochemical behaviour of sertraline hydrochloride at a
glassy carbon electrode and its determination in pharmaceutical products using
osteryoung square wave voltammetry. Pharmazie. 2010 Mar;65(3):182-7. PubMed PMID:
20383937.


9: Minagh E, Hernan R, O'Rourke K, Lyng FM, Davoren M. Aquatic ecotoxicity of the
selective serotonin reuptake inhibitor sertraline hydrochloride in a battery of
freshwater test species. Ecotoxicol Environ Saf. 2009 Feb;72(2):434-40. doi:
10.1016/j.ecoenv.2008.05.002. Epub 2008 Jun 20. PubMed PMID: 18571724.


10: Harada Y, Kohara N, Imaeda T. [Pharmacological, pharmacokinetic, and clinical
profile of sertraline hydrochloride (J ZOLOFT)]. Nihon Yakurigaku Zasshi. 2006
Dec;128(6):417-24. Review. Japanese. PubMed PMID: 17167216.


11: Arafa M, Shamloul R. Efficacy of sertraline hydrochloride in treatment of
premature ejaculation: a placebo-controlled study using a validated
questionnaire. Int J Impot Res. 2006 Nov-Dec;18(6):534-8. Epub 2006 Mar 23.
PubMed PMID: 16554853.


12: Zhou MX, Foley JP. Analytical method for the quantitation of sertraline
hydrochloride stereoisomers by electrokinetic chromatography. J Chromatogr A.
2004 Oct 15;1052(1-2):13-23. Review. PubMed PMID: 15527116.


13: Yalcin AU, Kudaiberdieva G, Sahin G, Gorenek B, Akcar N, Kuskus S, Bayrak F,
Timuralp B. Effect of sertraline hydrochloride on cardiac autonomic dysfunction
in patients with hemodialysis-induced hypotension. Nephron Physiol. 2003
Jan;93(1):P21-8. PubMed PMID: 12411727.


14: Yalcin AU, Sahin G, Erol M, Bal C. Sertraline hydrochloride treatment for
patients with hemodialysis hypotension. Blood Purif. 2002;20(2):150-3. PubMed
PMID: 11818677.


15: Davies TS, Kluwe WM. Preclinical toxicological evaluation of sertraline
hydrochloride. Drug Chem Toxicol. 1998 Nov;21(4):521-37. PubMed PMID: 10048942.


16: McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride.
Int J Impot Res. 1998 Sep;10(3):181-4; discussion 185. PubMed PMID: 9788108.


17: McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride:
a single-blind placebo controlled crossover study. J Urol. 1998
Jun;159(6):1935-8. PubMed PMID: 9598491.


18: Davies TS, Klowe WM. Preclinical toxicological evaluation of sertraline
hydrochloride. Drug Chem Toxicol. 1998 May;21(2):163-79. Corrected and
republished in: Drug Chem Toxicol. 1998 Nov;21(4):521-37. PubMed PMID: 9598298.


19: Dheenan S, Venkatesan J, Grubb BP, Henrich WL. Effect of sertraline
hydrochloride on dialysis hypotension. Am J Kidney Dis. 1998 Apr;31(4):624-30.
PubMed PMID: 9531178.


20: Grubb BP, Samoil D, Kosinski D, Kip K, Brewster P. Use of sertraline
hydrochloride in the treatment of refractory neurocardiogenic syncope in children
and adolescents. J Am Coll Cardiol. 1994 Aug;24(2):490-4. PubMed PMID: 8034887.