IU1
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407102

CAS#: 314245-33-5

Description: IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats. IU1 inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). IU1 stimulates proteasome activity and substrate degradation. USP14 removes the ubiquitin chain of I-κB, therefore inducing I-κB degradation and increasing cytokine release.


Price and Availability

Size
Price

5mg
USD 250
Size
Price

25mg
USD 650
Size
Price

IU1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407102
Name: IU1
CAS#: 314245-33-5
Chemical Formula: 18H21FN2O
Exact Mass: 300.16379
Molecular Weight: 300.37
Elemental Analysis: C, 71.98; H, 7.05; F, 6.32; N, 9.33; O, 5.33


Synonym: IU1; IU-1; IU 1

IUPAC/Chemical Name: 1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethan-1-one

InChi Key: JUWDSDKJBMFLHE-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3

SMILES Code: CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Santos AR, Mele M, Vaz SH, Kellermayer B, Grimaldi M, Colino-Oliveira M, Rombo DM, Comprido D, Sebastião AM, Duarte CB. Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP. J Neurosci. 2015 Feb 25;35(8):3319-29. doi: 10.1523/JNEUROSCI.4521-14.2015. PubMed PMID: 25716833.

2: Xu YH, Guo NL. USP14 inhibitor IU1 prevents ventilator-induced lung injury in rats. Cell Mol Biol (Noisy-le-grand). 2014 Sep 7;60(2):50-4. PubMed PMID: 25198582.

3: Ponnappan S, Palmieri M, Sullivan DH, Ponnappan U. Compensatory increase in USP14 activity accompanies impaired proteasomal proteolysis during aging. Mech Ageing Dev. 2013 Jan-Feb;134(1-2):53-9. doi: 10.1016/j.mad.2012.12.007. Epub 2013 Jan 3. PubMed PMID: 23291607; PubMed Central PMCID: PMC3558606.

4: Nag DK, Finley D. A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication. Virus Res. 2012 Apr;165(1):103-6. doi: 10.1016/j.virusres.2012.01.009. Epub 2012 Jan 26. PubMed PMID: 22306365.

5: Doucet D, Tyshenko MG, Davies PL, Walker VK. A family of expressed antifreeze protein genes from the moth, Choristoneura fumiferana. Eur J Biochem. 2002 Jan;269(1):38-46. PubMed PMID: 11784296.

6: Sun XL, Jayaram HN, Gharehbaghi K, Li QJ, Xiao X, Antony AC. Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity. Cancer Res. 1999 Feb 15;59(4):940-6. PubMed PMID: 10029088.

7: Bhuyan AK, Udgaonkar JB. Multiple kinetic intermediates accumulate during the unfolding of horse cytochrome c in the oxidized state. Biochemistry. 1998 Jun 23;37(25):9147-55. PubMed PMID: 9636061.

8: Helliwell M, Vale A, Goulding R. Haemoperfusion in 'late' paracetamol poisoning. Hum Toxicol. 1981;1(1):25-30. PubMed PMID: 7348690.

9: Goodman SR, Marrs BL, Narconis RJ, Olson RE. Isolation and description of a menaquinone mutant from Bacillus licheniformis. J Bacteriol. 1976 Jan;125(1):282-9. PubMed PMID: 1245457; PubMed Central PMCID: PMC233361.

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