L-744832

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406301

CAS#: 160141-09-3

Description: L-744832, also known as L-744,832, is a potent Farnesyltransferase inhibitor with potential anticancer activity.

Chemical Structure

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L-744832
CAS# 160141-09-3
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 406301
Name: L-744832
CAS#: 160141-09-3
Chemical Formula: C26H45N3O6S2
Exact Mass: 559.28
Molecular Weight: 559.782
Elemental Analysis: C, 55.79; H, 8.10; N, 7.51; O, 17.15; S, 11.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L744832; L 744832; L-744832

IUPAC/Chemical Name: (S)-isopropyl 2-((S)-2-(((2S,3S)-2-(((R)-2-amino-3-mercaptopropyl)amino)-3-methylpentyl)oxy)-3-phenylpropanamido)-4-(methylsulfonyl)butanoate

InChi Key: PGOKBMWPBDRDGN-IBXSQZDTSA-N

InChi Code: InChI=1S/C26H45N3O6S2/c1-6-19(4)23(28-15-21(27)17-36)16-34-24(14-20-10-8-7-9-11-20)25(30)29-22(12-13-37(5,32)33)26(31)35-18(2)3/h7-11,18-19,21-24,28,36H,6,12-17,27H2,1-5H3,(H,29,30)/t19-,21+,22-,23+,24-/m0/s1

SMILES Code: O=C(OC(C)C)[C@@H](NC([C@@H](OC[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CC1=CC=CC=C1)=O)CCS(=O)(C)=O

Appearance: Solid powder

Purity: >98%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:         

Product Data:
Product Data
Instruction:
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Biological target: L-744832, also known as L-744,832, is a potent Farnesyltransferase inhibitor with potential anticancer activity.
In vitro activity: Administration of L-744,832, neither alone nor its combination with 5-FU and radiation, affected the number of DLD-1 cells and apoptosis rates. Regarding its effects on the cell cycle, L-744,832 was shown to lead to G(0)/G(1) and G(2)/M accumulation in a dose-dependent manner when administered alone. However, in combination with 5-FU, only a G(0)/G(1) accumulation was observed. Reference: Chemotherapy. 2005 Oct;51(6):319-23. https://pubmed.ncbi.nlm.nih.gov/16224182/
In vivo activity: In syngeneic mice transplanted with the transgenic lymphoma cells, L-744,832 treatment prevented the growth of the tumor cells and the morbidity associated with the resulting lymphoma progression. Tumors that arose from transplantation of the lymphoma cells regressed with as little as three days of treatment with L-744,832 or SCH66336. Treatment of these established lymphomas with L-744,832 for seven days led to long-term remission of the disease in approximately 25% of animals. Reference: Mol Cancer. 2008 May 19;7:39. https://pubmed.ncbi.nlm.nih.gov/18489761/

Preparing Stock Solutions

The following data is based on the product molecular weight 559.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Kavgaci H, Ozdemir F, Ovali E, Yavuz A, Yavuz M, Aydin F. Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU. Chemotherapy. 2005 Oct;51(6):319-23. doi: 10.1159/000088954. Epub 2005 Oct 13. PMID: 16224182. 2. Kopec M, Strusinska K, Legat M, Makowski M, Jakobisiak M, Golab J. Potentiated antitumor effects of a combination therapy with a farnesyltransferase inhibitor L-744,832 and butyrate in vitro. Oncol Rep. 2004 May;11(5):1127-31. PMID: 15069557. 3. Gaylo AE, Laux KS, Batzel EJ, Berg ME, Field KA. Delayed rejection of MHC class II-disparate skin allografts in mice treated with farnesyltransferase inhibitors. Transpl Immunol. 2009 Jan;20(3):163-70. doi: 10.1016/j.trim.2008.09.011. Epub 2008 Oct 18. PMID: 18930822; PMCID: PMC7369389. 4. Field KA, Charoenthongtrakul S, Bishop JM, Refaeli Y. Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas. Mol Cancer. 2008 May 19;7:39. doi: 10.1186/1476-4598-7-39. PMID: 18489761; PMCID: PMC2409375.
In vitro protocol: 1. Kavgaci H, Ozdemir F, Ovali E, Yavuz A, Yavuz M, Aydin F. Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU. Chemotherapy. 2005 Oct;51(6):319-23. doi: 10.1159/000088954. Epub 2005 Oct 13. PMID: 16224182. 2. Kopec M, Strusinska K, Legat M, Makowski M, Jakobisiak M, Golab J. Potentiated antitumor effects of a combination therapy with a farnesyltransferase inhibitor L-744,832 and butyrate in vitro. Oncol Rep. 2004 May;11(5):1127-31. PMID: 15069557.
In vivo protocol: 1. Gaylo AE, Laux KS, Batzel EJ, Berg ME, Field KA. Delayed rejection of MHC class II-disparate skin allografts in mice treated with farnesyltransferase inhibitors. Transpl Immunol. 2009 Jan;20(3):163-70. doi: 10.1016/j.trim.2008.09.011. Epub 2008 Oct 18. PMID: 18930822; PMCID: PMC7369389. 2. Field KA, Charoenthongtrakul S, Bishop JM, Refaeli Y. Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas. Mol Cancer. 2008 May 19;7:39. doi: 10.1186/1476-4598-7-39. PMID: 18489761; PMCID: PMC2409375.

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