IOX 2
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 401512

CAS#: 931398-72-0

Description: IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). IOX 2 displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases.


Price and Availability

Size
Price

100mg
USD 850
1g
USD 3250
Size
Price

200mg
USD 1250
2g
USD 4650
Size
Price

500mg
USD 2150
5g
USD 6750

IOX 2, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 401512
Name: IOX 2
CAS#: 931398-72-0
Chemical Formula: C19H16N2O5
Exact Mass: 352.10592
Molecular Weight: 352.34
Elemental Analysis: C, 64.77; H, 4.58; N, 7.95; O, 22.70


Synonym: IOX2; IOX-2; IOX 2

IUPAC/Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine

InChi Key: CAOSCCRYLYQBES-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)

SMILES Code: O=C(O)CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98%

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

 1: Deppe J, Popp T, Egea V, Steinritz D, Schmidt A, Thiermann H, Weber C, Ries C.
Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts
by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol.
2015 Jun 17. [Epub ahead of print] PubMed PMID: 26082309.

2: Egert AM, Klotz JL, McLeod KR, Harmon DL. Development of a methodology to
measure the effect of ergot alkaloids on forestomach motility using real-time
wireless telemetry. Front Chem. 2014 Oct 13;2:90. doi: 10.3389/fchem.2014.00090.
eCollection 2014. PubMed PMID: 25353021; PubMed Central PMCID: PMC4195290.

3: Sen A, Ren S, Lerchenmüller C, Sun J, Weiss N, Most P, Peppel K. MicroRNA-138
regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1. PLoS
One. 2013 Nov 11;8(11):e78684. doi: 10.1371/journal.pone.0078684. eCollection
2013. Erratum in: PLoS One. 2013;8(12).
doi:10.1371/annotation/53080a85-89cc-4a84-8fd9-0eb0c19cc05d. PLoS One. 2014;9(1).
doi:10.1371/annotation/c7bddd8d-9f15-45f4-a886-740b351a39b6. PubMed PMID:
24244340; PubMed Central PMCID: PMC3823839.