WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406243
Description: BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18AÂ’s MT-stimulated ATPase activity, with an IC50 of 1.7Â–1.9 M . It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18AÂ’s MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the nature of Kif18AÂ’s double functionality within mitosis and assessing for potential therapeutic utilities.
MedKoo Cat#: 406243
Chemical Formula: C12H8ClNO4S
Exact Mass: 296.98626
Molecular Weight: 297.71
Elemental Analysis: C, 48.41; H, 2.71; Cl, 11.91; N, 4.70; O, 21.50; S, 10.77
Synonym: BTB1; BTB 1 ; BTB-1.
IUPAC/Chemical Name: 4-chloro-2-nitro-1-(phenylsulfonyl)benzene
InChi Key: VZDUQPHKUBZMLW-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H8ClNO4S/c13-9-6-7-12(11(8-9)14(15)16)19(17,18)10-4-2-1-3-5-10/h1-8H
SMILES Code: O=S(C1=CC=C(Cl)C=C1[N+]([O-])=O)(C2=CC=CC=C2)=O
1: Catarinella M, GrÃ¼ner T, Strittmatter T, Marx A, Mayer TU. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl. 2009;48(48):9072-6. doi: 10.1002/anie.200904510. PubMed PMID: 19856362.