AFG210

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406215

CAS#: 228400-22-4

Description: AFG210 is a novel first-generation “type II” FLT3 inhibitor.


Price and Availability

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AFG210, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406215
Name: AFG210
CAS#: 228400-22-4
Chemical Formula: C19H14F3N3O2
Exact Mass: 373.10381
Molecular Weight: 373.33
Elemental Analysis: C, 61.13; H, 3.78; F, 15.27; N, 11.26; O, 8.57


Synonym: AFG-210; AFG 210; AFG210.

IUPAC/Chemical Name: 1-(4-(pyridin-4-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

InChi Key: DDDLGNOZDKDSEG-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H14F3N3O2/c20-19(21,22)13-2-1-3-15(12-13)25-18(26)24-14-4-6-16(7-5-14)27-17-8-10-23-11-9-17/h1-12H,(H2,24,25,26)

SMILES Code: O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(OC3=CC=NC=C3)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1: Weisberg E, Roesel J, Furet P, Bold G, Imbach P, Flörsheimer A, Caravatti G, Jiang J, Manley P, Ray A, Griffin JD. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 Oct;1(10):1021-32. doi: 10.1177/1947601910396505. PubMed PMID: 21779428; PubMed Central PMCID: PMC3092267.