AFG206

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406214

CAS#: 630122-37-1

Description: AFG206 is the novel first-generation "type II" FLT3 inhibitor.


Price and Availability

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AFG206, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406214
Name: AFG206
CAS#: 630122-37-1
Chemical Formula: C20H19N3O2
Exact Mass: 333.14773
Molecular Weight: 333.38
Elemental Analysis: C, 72.05; H, 5.74; N, 12.60; O, 9.60


Synonym: AFG206; AFG 206; AFG-206.

IUPAC/Chemical Name: 1-(4-ethylphenyl)-3-(4-(pyridin-4-yloxy)phenyl)urea

InChi Key: UUJSPHQATNSVLQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H19N3O2/c1-2-15-3-5-16(6-4-15)22-20(24)23-17-7-9-18(10-8-17)25-19-11-13-21-14-12-19/h3-14H,2H2,1H3,(H2,22,23,24)

SMILES Code: O=C(NC1=CC=C(OC2=CC=NC=C2)C=C1)NC3=CC=C(CC)C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1:  Ellen Weisberg, Johannes Roesel, Pascal Furet, Guido Bold, Patricia Imbach, Andreas Flörsheimer, Georgio Caravatti, Jingrui Jiang, Paul Manley, Arghya Ray, James D. Griffin. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 October; 1(10): 1021–1032. doi: 10.1177/1947601910396505 PMCID: PMC3092267