AAE871

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406213

CAS#: 289479-07-8

Description: AAE871 is a type I FLT3 inhibitor.


Price and Availability

Size
Price

Size
Price

Size
Price

AEE871, purity > 98%, is not in stock, may be available through custom synthesis. Minimum 1 gram order is requested. Current shipping out time is about 70 days after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 406213
Name: AAE871
CAS#: 289479-07-8
Chemical Formula: C24H34N8O2S
Exact Mass: 498.25254
Molecular Weight: 498.64
Elemental Analysis: C, 57.81; H, 6.87; N, 22.47; O, 6.42; S, 6.43


Synonym: AAE871; AAE-871; AAE 871.

IUPAC/Chemical Name: N2-((1r,4r)-4-aminocyclohexyl)-9-ethyl-N6-(4-(piperidin-1-ylsulfonyl)phenyl)-9H-purine-2,6-diamine

InChi Key: IUUNTNJCKSXDOW-UAPYVXQJSA-N

InChi Code: InChI=1S/C24H34N8O2S/c1-2-31-16-26-21-22(29-24(30-23(21)31)28-19-8-6-17(25)7-9-19)27-18-10-12-20(13-11-18)35(33,34)32-14-4-3-5-15-32/h10-13,16-17,19H,2-9,14-15,25H2,1H3,(H2,27,28,29,30)/t17-,19-

SMILES Code: O=S(C1=CC=C(NC2=C3N=CN(CC)C3=NC(N[C@H]4CC[C@H](N)CC4)=N2)C=C1)(N5CCCCC5)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

1:  Ellen Weisberg, Johannes Roesel, Pascal Furet, Guido Bold, Patricia Imbach, Andreas Flörsheimer, Georgio Caravatti, Jingrui Jiang, Paul Manley, Arghya Ray, James D. Griffin. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 October; 1(10): 1021–1032. doi: 10.1177/1947601910396505 PMCID: PMC3092267