Desacetylrifampicin

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MedKoo CAT#: 125440

CAS#: 16783-99-6

Description: Desacetylrifampicin, also named as 25-Desacetyl Rifampicin, is the main metabolite of rifampicin.

Chemical Structure

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Desacetylrifampicin
CAS# 16783-99-6
Instruction

Theoretical Analysis

MedKoo Cat#: 125440
Name: Desacetylrifampicin
CAS#: 16783-99-6
Chemical Formula: C41H56N4O11
Exact Mass: 780.39
Molecular Weight: 780.920
Elemental Analysis: C, 63.06; H, 7.23; N, 7.17; O, 22.54

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Desacetylrifampicin; 25-Desacetyl Rifampicin; 16783-99-6; DESACETYLRIFAMPIN; 25-Deacetylrifampicin

IUPAC/Chemical Name: (7S,9E,11S,12S,13S,14R,15R,16R,17S,18S,19E,21Z)-2,13,15,17,27,29-hexahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaene-6,23-dione

InChi Key: KUJZTIJOBQNKDR-OACVHIRKSA-N

InChi Code: InChI=1S/C41H56N4O11/c1-20-11-10-12-21(2)40(53)43-31-26(19-42-45-16-14-44(8)15-17-45)36(50)28-29(37(31)51)35(49)25(6)38-30(28)39(52)41(7,56-38)55-18-13-27(54-9)22(3)33(47)24(5)34(48)23(4)32(20)46/h10-13,18-20,22-24,27,32-34,46-51H,14-17H2,1-9H3,(H,43,53)/b11-10+,18-13+,21-12-,42-19+/t20-,22+,23+,24-,27-,32-,33+,34+,41-/m0/s1

SMILES Code: O=C([C@@](O1)(C)O/C=C/[C@H](OC)[C@@H](C)[C@@H](O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C(C)\C(N2)=O)C3=C1C(C)=C(O)C4=C(O)C2=C(/C=N/N5CCN(C)CC5)C(O)=C43

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 780.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Oldfield S, Berg JD, Stiles HJ, Buckley BM. Measurement of rifampicin and
25-desacetylrifampicin in biological fluids using high-performance liquid
chromatography with direct sample injection. J Chromatogr. 1986 Apr
25;377:423-9. doi: 10.1016/s0378-4347(00)80804-x. PMID: 3711237.

2: Houin G, Beucler A, Richelet S, Brioude R, Lafaix C, Tillement JP.
Pharmacokinetics of rifampicin and desacetylrifampicin in tuberculous patients
after different rates of infusion. Ther Drug Monit. 1983;5(1):67-72. doi:
10.1097/00007691-198303000-00005. PMID: 6845401.

3: Guillaumont M, Leclercq M, Frobert Y, Guise B, Harf R. Determination of
rifampicin, desacetylrifampicin, isoniazid and acetylisoniazid by high-
performance liquid chromatography: application to human serum extracts,
polymorphonucleocytes and alveolar macrophages. J Chromatogr. 1982 Nov
12;232(2):369-76. doi: 10.1016/s0378-4347(00)84176-6. PMID: 7153283.

4: Ratti B, Parenti RR, Toselli A, Zerilli LF. Quantitative assay of rifampicin
and its main metabolite 25-desacetylrifampicin in human plasma by reversed-phase
high-performance liquid chromatography. J Chromatogr. 1981 Oct 9;225(2):526-31.
doi: 10.1016/s0378-4347(00)80308-4. PMID: 7298788.

5: Mouton RP, Mattie H, Swart K, Kreukniet J, de Wael J. Blood levels of
rifampicin, desacetylrifampicin and isoniazid during combined therapy. J
Antimicrob Chemother. 1979 Jul;5(4):447-54. doi: 10.1093/jac/5.4.447. PMID:
489492.

6: Manuĭlov KK, Gagaeva EV. Kolichestvennoe opredelenie rifampitsina i
25-dezatsetilrifampi- tsina v plazme s pomo'shchiu vysokoéffektivnoĭ zhidkostnoĭ
khromatografii [Quantitative analysis of rifampicin and 25-desacetylrifampicin
in the plasma using high performance liquid chromatography]. Antibiot Khimioter.
1989 Sep;34(9):682-4. Russian. PMID: 2610536.