Nek2 inhibitor V8

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MedKoo CAT#: 130542

CAS#: Nek2 inhibitor V8

Description: Nek2 inhibitor V8 is a novel potent inhibitor of NIMA Related Kinase 2 (Nek2) kinase (IC50 = 2.4±0.2µM). It attenuates pAkt/PI3 Kinase signaling and proliferative and migratory phenotypes of highly aggressive human MDA-MB-231 breast and A549 lung cancer cell lines.

Chemical Structure

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Nek2 inhibitor V8
CAS# Nek2 inhibitor V8
Instruction

Theoretical Analysis

MedKoo Cat#: 130542
Name: Nek2 inhibitor V8
CAS#: Nek2 inhibitor V8
Chemical Formula: C14H16BrN3O3S
Exact Mass: 385.01
Molecular Weight: 386.260
Elemental Analysis: C, 43.53; H, 4.18; Br, 20.69; N, 10.88; O, 12.43; S, 8.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: V8, Nek2 inhibitor-V8, Nek2 In V8, Nek2 In-V8, Nek2-In-V8

IUPAC/Chemical Name: 3-(4-Bromophenyl)-8-(methylsulfonyl)-1,4,8-triazaspiro[4.5]dec-3-en-2-one

InChi Key: PTJHYSBTEDYVLZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H16BrN3O3S/c1-22(20,21)18-8-6-14(7-9-18)16-12(13(19)17-14)10-2-4-11(15)5-3-10/h2-5H,6-9H2,1H3,(H,17,19)

SMILES Code: O=C1NC2(CCN(S(=O)(C)=O)CC2)N=C1C3=CC=C(Br)C=C3

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 386.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Bhuiyan AI, Choi AH, Ghoshal S, Adiele UA, Dana D, Choi JY, Fath KR, Talele TT, Pathak SK. Identification of a novel spirocyclic Nek2 inhibitor using high throughput virtual screening. Bioorg Med Chem Lett. 2023 May 15;88:129288. doi: 10.1016/j.bmcl.2023.129288. Epub 2023 Apr 23. PMID: 37094724.