CHD1Li 6.11
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MedKoo CAT#: 208296

CAS#: 2716890-91-2

Description: CHD1Li 6.11 is an inhibitor of Chromodomain helicase DNA-binding protein 1 like (CHD1L), which is an oncogene implicated in tumor progression, multidrug resistance, and metastasis in many types of cancer. CHD1Li 6.11 proved to be an orally bioavailable antitumor agent, significantly reducing the tumor volume of CRC xenografts generated from isolated quasi mesenchymal cells (M-phenotype), which possess enhanced tumorigenic properties.

Chemical Structure

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CHD1Li 6.11
CAS# 2716890-91-2
Instruction

Theoretical Analysis

MedKoo Cat#: 208296
Name: CHD1Li 6.11
CAS#: 2716890-91-2
Chemical Formula: C21H22BrN5OS
Exact Mass: 471.07
Molecular Weight: 472.410
Elemental Analysis: C, 53.39; H, 4.69; Br, 16.91; N, 14.83; O, 3.39; S, 6.79

Price and Availability

Size Price Availability Quantity
25mg USD 450 2 Weeks
50mg USD 750 2 Weeks
100mg USD 1250 2 Weeks
200mg USD 1850 2 Weeks
500mg USD 2950 2 Weeks
1g USD 4450 2 Weeks
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Synonym: CHD1Li6.11, CHD1Li-6.11; CHD1Li 611; CHD1Li-611; CHD1Li611;

IUPAC/Chemical Name: 2-(4-Bromothiophen-2-yl)-N-(4-((6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)acetamide

InChi Key: ACDZBXZERLBYOW-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22BrN5OS/c1-14-10-19(26-21(23-14)27-8-2-3-9-27)24-16-4-6-17(7-5-16)25-20(28)12-18-11-15(22)13-29-18/h4-7,10-11,13H,2-3,8-9,12H2,1H3,(H,25,28)(H,23,24,26)

SMILES Code: O=C(NC1=CC=C(NC2=NC(N3CCCC3)=NC(C)=C2)C=C1)CC4=CC(Br)=CS4

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 472.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Prigaro BJ, Esquer H, Zhou Q, Pike LA, Awolade P, Lai XH, Abraham AD, Abbott JM, Matter B, Kompella UB, Messersmith WA, Gustafson DL, LaBarbera DV. Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L. J Med Chem. 2022 Mar 10;65(5):3943-3961. doi: 10.1021/acs.jmedchem.1c01778. Epub 2022 Feb 22. PMID: 35192363; PMCID: PMC8981980.