KL-11743
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MedKoo CAT#: 208129

CAS#: 1369452-53-8

Description: KL-11743 is a representative compound that blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate.

Chemical Structure

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KL-11743
CAS# 1369452-53-8
Instruction

Theoretical Analysis

MedKoo Cat#: 208129
Name: KL-11743
CAS#: 1369452-53-8
Chemical Formula: C30H30N6O3
Exact Mass: 522.24
Molecular Weight: 522.610
Elemental Analysis: C, 68.95; H, 5.79; N, 16.08; O, 9.18

Price and Availability

Size Price Availability Quantity
25mg USD -2 2 Weeks
50mg USD 1650 2 Weeks
100mg USD 2850 2 Weeks
200mg USD 4250 2 Weeks
500mg USD 7650 2 Weeks
1g USD 9850 2 Weeks
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Synonym: KL-11743; KL 11743; KL11743

IUPAC/Chemical Name: 2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-6-ethoxyquinazolin-2-yl)phenoxy)-N-isopropylacetamide

InChi Key: XKOYTLRGOQTKAU-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H30N6O3/c1-4-38-25-12-13-27-26(15-25)30(34-23-10-8-20(9-11-23)22-16-31-32-17-22)36-29(35-27)21-6-5-7-24(14-21)39-18-28(37)33-19(2)3/h5-17,19H,4,18H2,1-3H3,(H,31,32)(H,33,37)(H,34,35,36)

SMILES Code: CC(C)NC(COC1=CC(C2=NC(NC3=CC=C(C4=CNN=C4)C=C3)=C(C=C(OCC)C=C5)C5=N2)=CC=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 522.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Olszewski K, Barsotti A, Feng XJ, Momcilovic M, Liu KG, Kim JI, Morris K, Lamarque C, Gaffney J, Yu X, Patel JP, Rabinowitz JD, Shackelford DB, Poyurovsky MV. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2022 Mar 17;29(3):423-435.e10. doi: 10.1016/j.chembiol.2021.10.007. Epub 2021 Oct 28. PMID: 34715056.