Glufosinate-d3 HCl
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MedKoo CAT#: 464992

CAS#: 1323254-05-2

Description: Glufosinate-d3 is intended for use as an internal standard for the quantification of glufosinate by GC- or LC-MS. Glufosinate is a broad-spectrum herbicide and racemic mixture of L-phosphinothricin, a phytotoxic compound, and D-phosphinothricin, its inactive enantiomer. It is an irreversible inhibitor of glufosinate synthetase 1 (GS1) and GS2 (Kis = 1.1. and 4.8 µM, respectively), enzymes that are required for nitrogen metabolism in plants. Glufosinate induces the production of reactive oxygen species (ROS) and lipid peroxidation in plant cell membranes. It reduces dry biomass of the weeds E. canadensis and L. rigidum with ED50 values of 26 and 763 g/hectare, respectively. Glufosinate has no observed adverse effects in rats and mice when administered at doses of 4.1 and 17 mg/kg per day for three months. Formulations containing glufosinate have been used as foliar herbicides in agriculture.

Chemical Structure

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Glufosinate-d3 HCl
CAS# 1323254-05-2
Instruction

Theoretical Analysis

MedKoo Cat#: 464992
Name: Glufosinate-d3 HCl
CAS#: 1323254-05-2
Chemical Formula: C5H10D3ClNO4P
Exact Mass: 220.05
Molecular Weight: 220.604
Elemental Analysis: C, 27.22; H, 7.31; Cl, 16.07; N, 6.35; O, 29.01; P, 14.04

Price and Availability

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1mg USD 660 2 Weeks
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Synonym: Glufosinate-d3 HCl; Glufosinate d3 HCl; Glufosinate-d3 hydrochloride; Glufosinate d3 hydrochloride;

IUPAC/Chemical Name: 2-amino-4-(hydroxy(methyl-d3)phosphoryl)butanoic acid hydrochloride

InChi Key: GCZPTWOGXDBENT-NIIDSAIPSA-N

InChi Code: InChI=1S/C5H12NO4P.ClH/c1-11(9,10)3-2-4(6)5(7)8;/h4H,2-3,6H2,1H3,(H,7,8)(H,9,10);1H/i1D3;

SMILES Code: OC(C(CCP(C([2H])([2H])[2H])(O)=O)N)=O.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 220.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yeon S, Kim SH, Sim J, Kim S, Lee Y, Kim H, Cha YS. Major component causing neurological toxicity in acute glufosinate ammonium poisoning: determination of glufosinate, 1-methoxy-2-propanol, and ammonia in serum and cerebrospinal fluid. Clin Toxicol (Phila). 2021 Jul 16:1-7. doi: 10.1080/15563650.2021.1952215. Epub ahead of print. PMID: 34269144.