UAMC1110-NH2
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MedKoo CAT#: 555986

CAS#: 2758337-19-6

Description: UAMC1110-NH2 is a derivative of UAMC1110 with a aminobutoxy group, which is useful to synthesie UAMC1110 conjugate. UAMC-1110, also known as SP-13786, is a novel potent and selective inhibitor of fibroblast activation protein (fap), displaying low nanomolar inhibitory potency and high selectivity against the related dipeptidyl peptidases (dpps) dppiv, dpp9, dppii, and prolyl oligopeptidase (prep).

Chemical Structure

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UAMC1110-NH2
CAS# 2758337-19-6
Instruction

Theoretical Analysis

MedKoo Cat#: 555986
Name: UAMC1110-NH2
CAS#: 2758337-19-6
Chemical Formula: C21H23F2N5O3
Exact Mass: 431.18
Molecular Weight: 431.444
Elemental Analysis: C, 58.46; H, 5.37; F, 8.81; N, 16.23; O, 11.12

Price and Availability

Size Price Availability Quantity
100mg USD 3850 2 Weeks
200mg USD 5850 2 Weeks
500mg USD 7950 2 Weeks
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Synonym: UAMC1110-NH2; UAMC 1110-NH2; UAMC-1110-NH2; NH2-UAMC1110; NH2-UAMC-1110; Amino-UAMC1110;

IUPAC/Chemical Name: (S)-6-(4-aminobutoxy)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide

InChi Key: WDZAGMQBKLWFSD-AWEZNQCLSA-N

InChi Code: InChI=1S/C21H23F2N5O3/c22-21(23)10-14(11-25)28(13-21)19(29)12-27-20(30)16-5-7-26-18-4-3-15(9-17(16)18)31-8-2-1-6-24/h3-5,7,9,14H,1-2,6,8,10,12-13,24H2,(H,27,30)/t14-/m0/s1

SMILES Code: O=C(C1=CC=NC2=CC=C(OCCCCN)C=C12)NCC(N3[C@H](C#N)CC(F)(F)C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 431.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: De Decker A, Vliegen G, Van Rompaey D, Peeraer A, Bracke A, Verckist L, Jansen K, Geiss-Friedlander R, Augustyns K, De Winter H, De Meester I, Lambeir AM, Van der Veken P. Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP). ACS Med Chem Lett. 2019 Jul 9;10(8):1173-1179. doi: 10.1021/acsmedchemlett.9b00191. PMID: 31413802; PMCID: PMC6691567.


2: Moon ES, Elvas F, Vliegen G, De Lombaerde S, Vangestel C, De Bruycker S, Bracke A, Eppard E, Greifenstein L, Klasen B, Kramer V, Staelens S, De Meester I, Van der Veken P, Rösch F. Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19. doi: 10.1186/s41181-020-00102-z. PMID: 32728930; PMCID: PMC7391456.


3: Gunderson AJ, Yamazaki T, McCarty K, Phillips M, Alice A, Bambina S, Zebertavage L, Friedman D, Cottam B, Newell P, Gough MJ, Crittenden MR, Van der Veken P, Young KH. Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma. PLoS One. 2019 Feb 6;14(2):e0211117. doi: 10.1371/journal.pone.0211117. PMID: 30726287; PMCID: PMC6364920.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391456/