Celastrol
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 200694

CAS#: 34157-83-0 (castrol)

Description: Celastrol, also known as tripterine, is a remedial ingredient isolated from the root extracts of Tripterygium Wilfordi (Thunder of God vine) and Celastrus Regelii. In in vitro and in vivo animal experiments, celastrol exhibits antioxidant, anti-inflammatory, anticancer, and insecticidal activities. Celastrol has attracted great interest recently, especially for its potential anti-inflammatory and anti-cancer activities. The anti-inflammatory effects of this triterpene have been demonstrated in animal models of different inflammatory diseases, including arthritis, Alzheimer's disease, asthma, and systemic lupus erythematosus.


Price and Availability

Size
Price

25mg
USD 90
200mg
USD 350
2g
USD 950
20g
USD 3750
Size
Price

50mg
USD 150
500mg
USD 450
5g
USD 1650
50g
USD 6950
Size
Price

100mg
USD 250
1g
USD 550
10g
USD 2750
100g
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Celastrol, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 200694
Name: Celastrol
CAS#: 34157-83-0 (castrol)
Chemical Formula: C29H38O4
Exact Mass: 450.27701
Molecular Weight: 450.61
Elemental Analysis: C, 77.30; H, 8.50; O, 14.20


Related CAS #: 34157-83-0 (castrol)   193957-88-9 (dihydrocelastrol)    

Synonym: Tripterine; Celastrol; Tripterin.

IUPAC/Chemical Name: (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid

InChi Key: KQJSQWZMSAGSHN-JJWQIEBTSA-N

InChi Code: InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1

SMILES Code: O=C([C@@](CC[C@]1(C)CC[C@]2(C)C3=CC=C4C(C)=C5O)(C)C[C@@]1([H])[C@]2(C)CC[C@@]3(C)C4=CC5=O)O


Technical Data

Appearance:
Red solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO (45 mg/ml) or Ethanol (30 mg/ml), not soluble in water.

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

 
   
 
 


References

1: Deane CA, Brown IR. Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol. Cell Stress Chaperones. 2016 Jun 8. [Epub ahead of print] PubMed PMID: 27273088.

2: Aqil F, Kausar H, Agrawal AK, Jeyabalan J, Kyakulaga AH, Munagala R, Gupta R. Exosomal formulation enhances therapeutic response of celastrol against lung cancer. Exp Mol Pathol. 2016 May 24;101(1):12-21. doi: 10.1016/j.yexmp.2016.05.013. [Epub ahead of print] PubMed PMID: 27235383.

3: Shen YF, Zhang X, Wang Y, Cao FF, Uzan G, Peng B, Zhang DH. Celastrol targets IRAKs to block Toll-like receptor 4-mediated nuclear factor-κB activation. J Integr Med. 2016 May;14(3):203-8. doi: 10.1016/S2095-4964(16)60257-1. PubMed PMID: 27181127.

4: Chang W, He W, Li PP, Song SS, Yuan PF, Lu JT, Wei W. Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. Eur J Pharmacol. 2016 May 12;784:173-180. doi: 10.1016/j.ejphar.2016.04.045. [Epub ahead of print] PubMed PMID: 27181068.

5: Choi JY, Ramasamy T, Kim SY, Kim J, Ku SK, Youn YS, Kim JR, Jeong JH, Choi HG, Yong CS, Kim JO. PEGylated lipid bilayer-supported mesoporous silica nanoparticle composite for synergistic co-delivery of axitinib and celastrol in multi-targeted cancer therapy. Acta Biomater. 2016 Jul 15;39:94-105. doi: 10.1016/j.actbio.2016.05.012. Epub 2016 May 6. PubMed PMID: 27163403.

6: Cheng M, Wu G, Song Y, Wang L, Tu L, Zhang L, Zhang C. Celastrol-Induced Suppression of the MiR-21/ERK Signalling Pathway Attenuates Cardiac Fibrosis and Dysfunction. Cell Physiol Biochem. 2016;38(5):1928-38. doi: 10.1159/000445554. Epub 2016 May 9. PubMed PMID: 27160852.

7: Li H, Li J, Liu L, Zhang Y, Luo Y, Zhang X, Yang P, Zhang M, Yu W, Qu S. Elucidation of the Intestinal Absorption Mechanism of Celastrol Using the Caco-2 Cell Transwell Model. Planta Med. 2016 May 9. [Epub ahead of print] PubMed PMID: 27159672.

8: Yu X, Ruan X, Zhang J, Zhao Q. Celastrol Induces Cell Apoptosis and Inhibits the Expression of the AML1-ETO/C-KIT Oncoprotein in t(8;21) Leukemia. Molecules. 2016 Apr 30;21(5). pii: E574. doi: 10.3390/molecules21050574. PubMed PMID: 27144550.

9: Kapoor S. Tumor Growth Attenuating Effect of Celastrol In Systemic Malignancies. Int J Cancer. 2016 Apr 20. doi: 10.1002/ijc.30151. [Epub ahead of print] PubMed PMID: 27097353.

10: Choi SK, Park S, Jang S, Cho HH, Lee S, You S, Kim SH, Moon HS. Cascade regulation of PPARγ(2) and C/EBPα signaling pathways by celastrol impairs adipocyte differentiation and stimulates lipolysis in 3T3-L1 adipocytes. Metabolism. 2016 May;65(5):646-54. doi: 10.1016/j.metabol.2016.01.009. Epub 2016 Jan 25. PubMed PMID: 27085773.

11: Pazhang Y, Jaliani HZ, Imani M, Dariushnejad H. Synergism between NF-kappa B inhibitor, celastrol, and XIAP inhibitor, embelin, in an acute myeloid leukemia cell line, HL-60. J Cancer Res Ther. 2016 Jan-Mar;12(1):155-60. doi: 10.4103/0973-1482.150407. PubMed PMID: 27072230.

12: Han LP, Li CJ, Sun B, Xie Y, Guan Y, Ma ZJ, Chen LM. Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic Rats. J Diabetes Res. 2016;2016:2641248. doi: 10.1155/2016/2641248. Epub 2016 Jan 19. PubMed PMID: 27057550; PubMed Central PMCID: PMC4745324.

13: Guan Y, Cui ZJ, Sun B, Han LP, Li CJ, Chen LM. Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway. Int J Mol Med. 2016 May;37(5):1229-38. doi: 10.3892/ijmm.2016.2549. Epub 2016 Apr 5. PubMed PMID: 27049825; PubMed Central PMCID: PMC4829141.

14: Zou YC, Yang XW, Yuan SG, Zhang P, Li YK. Celastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro. Drug Des Devel Ther. 2016 Mar 7;10:933-48. doi: 10.2147/DDDT.S97463. eCollection 2016. PubMed PMID: 27022241; PubMed Central PMCID: PMC4790082.

15: Wang R, Gu X, Dai W, Ye J, Lu F, Chai Y, Fan G, Gonzalez FJ, Duan G, Qi Y. A lipidomics investigation into the intervention of celastrol in experimental colitis. Mol Biosyst. 2016 Apr 26;12(5):1436-44. doi: 10.1039/c5mb00864f. PubMed PMID: 27021137.

16: Liu X, Cai F, Zhang Y, Yang A, Liu L. Celastrol, an NF-κB inhibitor, ameliorates hypercalciuria and articular cartilage lesions in a mouse model of secondary osteoporosis. J Pharmacol Sci. 2016 Apr;130(4):204-11. doi: 10.1016/j.jphs.2016.02.001. Epub 2016 Feb 8. PubMed PMID: 26980429.

17: Bian M, Du X, Cui J, Wang P, Wang W, Zhu W, Zhang T, Chen Y. Celastrol protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation. J Neuroinflammation. 2016 Feb 27;13:50. doi: 10.1186/s12974-016-0516-8. PubMed PMID: 26920853; PubMed Central PMCID: PMC4769581.

18: Lin L, Sun Y, Wang D, Zheng S, Zhang J, Zheng C. Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition. Front Pharmacol. 2016 Jan 13;6:320. doi: 10.3389/fphar.2015.00320. eCollection 2015. PubMed PMID: 26793111; PubMed Central PMCID: PMC4711309.

19: Liu YJ, Zhao YJ, Su P, Zhang M, Tong YR, Hu TY, Huang LQ, Gao W. The MVA pathway genes expressions and accumulation of celastrol in Tripterygium wilfordii suspension cells in response to methyl jasmonate treatment. J Asian Nat Prod Res. 2016 Jul;18(7):619-28. doi: 10.1080/10286020.2015.1134504. Epub 2016 Jan 19. PubMed PMID: 26785825.

20: Divya T, Dineshbabu V, Soumyakrishnan S, Sureshkumar A, Sudhandiran G. Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis. Chem Biol Interact. 2016 Feb 25;246:52-62. doi: 10.1016/j.cbi.2016.01.006. Epub 2016 Jan 6. PubMed PMID: 26768587.