Chonemorphine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412846

CAS#: 4282-07-9

Description: Chonemorphine is a steroidal alkaloid; antiparasitic agent from Chonemorpha fragrans.


Chemical Structure

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Chonemorphine
CAS# 4282-07-9

Theoretical Analysis

MedKoo Cat#: 412846
Name: Chonemorphine
CAS#: 4282-07-9
Chemical Formula: C23H42N2
Exact Mass: 346.33
Molecular Weight: 346.600
Elemental Analysis: C, 79.70; H, 12.21; N, 8.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Chonemorphine; UNII-3AYM0KA3QK

IUPAC/Chemical Name: Pregnane-3,20-diamine, N20,N20-dimethyl-, (3beta,5alpha,20S)-

InChi Key: MJGLREGOLPEPID-GHKGYAFRSA-N

InChi Code: InChI=1S/C23H42N2/c1-15(25(4)5)19-8-9-20-18-7-6-16-14-17(24)10-12-22(16,2)21(18)11-13-23(19,20)3/h15-21H,6-14,24H2,1-5H3/t15-,16-,17-,18-,19+,20-,21-,22-,23+/m0/s1

SMILES Code: C[C@H](N(C)C)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@@H](N)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 346.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Shah VC, D'Sa AS, de Souza NJ. Chonemorphine, stigmasterol, and ecdysterone: steroids isolated through bioassay-directed plant screening programs. Steroids. 1989 Mar-May;53(3-5):559-65. doi: 10.1016/0039-128x(89)90031-7. PMID: 2799857.

2: Chatterjee DK, Iyer N, Ganguli BN. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res. 1987;74(1):30-3. doi: 10.1007/BF00534928. PMID: 2894025.

3: Rathnayake S, Weerasinghe S. Exploring the binding properties of agonists interacting with glucocorticoid receptor: an in silico approach. J Mol Model. 2018 Nov 20;24(12):342. doi: 10.1007/s00894-018-3879-1. PMID: 30460461.

4: Shah V, Sunder R, de Souza NJ. Chonemorphine and rapanone--antiparasitic agents from plant sources. J Nat Prod. 1987 Jul-Aug;50(4):730-1. doi: 10.1021/np50052a026. PMID: 3430168.

5: GURUSWAMI MN. Chonemorphine: some pharmacological actions. Preliminary report. Indian J Med Sci. 1960 Apr;14:338-43. PMID: 13830383.

6: Jayasinghe UL, Kumarihamya BM, Nadeemb M, Choudhary MI, Atta-Ur-Rahmanb, Weerasooriya A. Iso-N-formyl-5-en-chonemorphine, a steroidal alkaloid from Sarcococca zeylanica. Nat Prod Lett. 2001;15(3):151-5. doi: 10.1080/10575630108041274. PMID: 11858546.

7: Kulkarni AV, Patwardhan AA, Lele U, Malpathak NP. Production of camptothecin in cultures of Chonemorpha grandiflora. Pharmacognosy Res. 2010 Sep;2(5):296-9. doi: 10.4103/0974-8490.72327. PMID: 21589755; PMCID: PMC3093040.

8: Devkota KP, Wansi JD, Lenta BN, Khan S, Choudhary MI, Sewald N. Bioactive steroidal alkaloids from Sarcococca hookeriana. Planta Med. 2010 Jul;76(10):1022-5. doi: 10.1055/s-0029-1240896. Epub 2010 Feb 25. PMID: 20186658.