Cgs 27830

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412776

CAS#: 155485-56-6

Description: Cgs 27830 is an Endothelin Receptor Antagonist.

Chemical Structure

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Cgs 27830
CAS# 155485-56-6
Instruction

Theoretical Analysis

MedKoo Cat#: 412776
Name: Cgs 27830
CAS#: 155485-56-6
Chemical Formula: C32H30N4O11
Exact Mass: 646.19
Molecular Weight: 646.600
Elemental Analysis: C, 59.44; H, 4.68; N, 8.66; O, 27.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Cgs 27830; Cgs-27830; Cgs27830

IUPAC/Chemical Name: meso-1,4-Dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridine carboxylic acid anhydride

InChi Key: PZNZOWSLQRURNA-HNRBIFIRSA-N

InChi Code: InChI=1S/C32H30N4O11/c1-15-23(29(37)45-5)27(19-9-7-11-21(13-19)35(41)42)25(17(3)33-15)31(39)47-32(40)26-18(4)34-16(2)24(30(38)46-6)28(26)20-10-8-12-22(14-20)36(43)44/h7-14,27-28,33-34H,1-6H3/t27-,28+

SMILES Code: O=C(OC(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC=CC([N+]([O-])=O)=C2)=O)C3=C(C)NC(C)=C(C(OC)=O)[C@H]3C4=CC=CC([N+]([O-])=O)=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 646.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mateo AO, de Artiñano MA. Effect of high extracellular Ca(2+) levels in spontaneously hypertensive rat aorta. Eur J Pharmacol. 2001 Dec 7;432(2-3):177-85. doi: 10.1016/s0014-2999(01)01415-7. PMID: 11740954.

2: Chin MH, Cioffi CL, Garay M, Neale RF, Shetty SS, DelGrande D, Mugrage B, Sills MA, Lipson KE. The unusual binding properties of the endothelin receptor antagonist CGS 27830 distinguishes receptor/agonist interactions. J Pharmacol Exp Ther. 1996 Jan;276(1):74-83. PMID: 8558459.

3: Ivy DD, Kinsella JP, Abman SH. Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation. J Clin Invest. 1994 May;93(5):2141-8. doi: 10.1172/JCI117210. PMID: 8182146; PMCID: PMC294348.