CGS20625
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412756

CAS#: 111205-55-1

Description: CGS-20625 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It produces anxiolytic and anticonvulsant effects, but with no sedative effects even at high doses, and no significant muscle relaxant effects. It is orally active in humans, but with relatively low bioavailability. CGS-20625 is a positive allosteric modulator at several GABAA receptors types. Due to its alicyclic moiety potency at γ1 subunit, containing receptor types is more pronounced for CGS-20625 compared to benzodiazepines. γ1 subunits are expressed at higher levels in the central amygdala.

Chemical Structure

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CGS20625
CAS# 111205-55-1
Instruction

Theoretical Analysis

MedKoo Cat#: 412756
Name: CGS20625
CAS#: 111205-55-1
Chemical Formula: C18H19N3O2
Exact Mass: 309.15
Molecular Weight: 309.370
Elemental Analysis: C, 69.88; H, 6.19; N, 13.58; O, 10.34

Price and Availability

Size Price Availability Quantity
50mg USD 550 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2950 2 Weeks
1g USD 4250 2 Weeks
2g USD 6650 2 Weeks
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Synonym: CGS20625; CGS-20625; CGS 20625;

IUPAC/Chemical Name: Cyclohepta(b)pyrazolo(3,4-d)pyridin-3(2H)-one, 5,6,7,8,9,10-hexahydro-2-(4-methoxyphenyl)-

InChi Key: XRUUVUYJUULCBQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H19N3O2/c1-23-13-9-7-12(8-10-13)21-18(22)15-11-19-16-6-4-2-3-5-14(16)17(15)20-21/h7-11,19H,2-6H2,1H3

SMILES Code: O=C1N(C2=CC=C(OC)C=C2)N=C3C(CCCCC4)=C4NC=C31

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 309.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hirschberg Y, Oberle RL, Ortiz M, Lau H, Markowska M. Oral absorption of CGS-20625, an insoluble drug, in dogs and man. J Pharmacokinet Biopharm. 1995 Feb;23(1):11-23. doi: 10.1007/BF02353783. PMID: 8576841.

2: Williams M, Bennett DA, Loo PS, Braunwalder AF, Amrick CL, Wilson DE, Thompson TN, Schmutz M, Yokoyoma N, Wasley JW. CGS 20625, a novel pyrazolopyridine anxiolytic. J Pharmacol Exp Ther. 1989 Jan;248(1):89-96. PMID: 2563294.

3: Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S. Pharmacological properties of GABAA receptors containing gamma1 subunits. Mol Pharmacol. 2006 Feb;69(2):640-9. doi: 10.1124/mol.105.017236. Epub 2005 Nov 4. PMID: 16272224.

4: Jarvis MF, Bennett DA, Loo PA, Braunwalder AF, Thompson TN, Schmutz M, Yokoyoma N, Wasley JW, Williams M. CGS 20625, a novel pyrazolopyridine with selective anxiolytic activity. Prog Clin Biol Res. 1990;361:477-82. PMID: 1981266.

5: Tang AH, Franklin SR. The discriminative stimulus effects of diazepam in rats at two training doses. J Pharmacol Exp Ther. 1991 Sep;258(3):926-31. PMID: 1679851.

6: Brunner LA, Luders RC. Determination of a potential anxiolytic drug (CGS 20625) in human plasma by high-performance liquid chromatography. J Chromatogr. 1991 Aug 23;568(2):487-93. doi: 10.1016/0378-4347(91)80188-i. PMID: 1686029.

7: Bennett DA. Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions. Physiol Behav. 1987;41(3):241-5. doi: 10.1016/0031-9384(87)90360-x. PMID: 2893398.

8: Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W. Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit. Biochem Pharmacol. 2004 Oct 15;68(8):1621-9. doi: 10.1016/j.bcp.2004.07.020. PMID: 15451405.