CGS-18102A free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412752

CAS#: 100746-35-8

Description: CGS-18102A free base is a biochemical

Chemical Structure

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CGS-18102A free base
CAS# 100746-35-8
Instruction

Theoretical Analysis

MedKoo Cat#: 412752
Name: CGS-18102A free base
CAS#: 100746-35-8
Chemical Formula: C16H23NO2
Exact Mass: 261.17
Molecular Weight: 261.370
Elemental Analysis: C, 73.53; H, 8.87; N, 5.36; O, 12.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CGS-18102A free base; UNII-N120ZZL44H

IUPAC/Chemical Name: (4aR,10bS)-10-methoxy-4-propyl-1,3,4,4a,5,10b-hexahydro-2H-chromeno[3,4-b]pyridine

InChi Key: AIMYJNFPNLKTCY-OLZOCXBDSA-N

InChi Code: InChI=1S/C16H23NO2/c1-3-9-17-10-5-6-12-13(17)11-19-15-8-4-7-14(18-2)16(12)15/h4,7-8,12-13H,3,5-6,9-11H2,1-2H3/t12-,13+/m1/s1

SMILES Code: CCCN1CCC[C@@H]2[C@@H]1COc3c2c(OC)ccc3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 261.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sills MA, Bennett DA, Lovell RA, Liebman JM, Wood PL, Glaeser BS, Williams M, Hutchison AJ. CGS 18102A, a benzopyranopyridine anxiolytic with 5-HT1 agonist and 5-HT2 antagonist properties. Prog Clin Biol Res. 1990;361:469-75. PMID: 1981265.

2: Kleven MS, Assié MB, Koek W. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT(2A/2C) antagonist anxiolytics. II. Drug discrimination and behavioral observation studies in rats. J Pharmacol Exp Ther. 1997 Aug;282(2):747-59. PMID: 9262338.

3: Kleven MS, Koek W. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon. J Pharmacol Exp Ther. 1996 Feb;276(2):388-97. PMID: 8632301.

4: Leal M, Hayes MJ, Powell ML. Quantitative determination of CGS 18102A, a new anxiolytic, in human plasma using capillary gas chromatography/mass spectrometry. Biomed Chromatogr. 1992 Sep-Oct;6(5):244-7. doi: 10.1002/bmc.1130060509. PMID: 1361157.

5: Stelling MS, Maniara WM, Powell ML. A quantitative analytical method for the determination of a new anxiolytic (CGS 19480A) in human plasma using high performance liquid chromatography. Biomed Chromatogr. 1994 Nov-Dec;8(6):288-90. doi: 10.1002/bmc.1130080607. PMID: 7888731.