Aminochlorambucil

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462991

CAS#: 3688-35-5

Description: Aminochlorambucil is a biochemical that has shown to have an immunosuppressive effect on adjuvant arthritis in rats.

Chemical Structure

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Aminochlorambucil
CAS# 3688-35-5
Instruction

Theoretical Analysis

MedKoo Cat#: 462991
Name: Aminochlorambucil
CAS#: 3688-35-5
Chemical Formula: C14H20Cl2N2O2
Exact Mass: 318.09
Molecular Weight: 319.226
Elemental Analysis: C, 52.68; H, 6.32; Cl, 22.21; N, 8.78; O, 10.02

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: NSC 260461; NSC-260461; NSC260461;

IUPAC/Chemical Name: 2-amino-4-(4-(bis(2-chloroethyl)amino)phenyl)butanoic acid

InChi Key: WBIFEHLOTPXXKS-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H20Cl2N2O2/c15-7-9-18(10-8-16)12-4-1-11(2-5-12)3-6-13(17)14(19)20/h1-2,4-5,13H,3,6-10,17H2,(H,19,20)

SMILES Code: NC(C(O)=O)CCc1ccc(N(CCCl)CCCl)cc1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 319.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Redel J, Brouilhet H, Bazely N, Marchal S, Rabaud M, Delbarre F. Réactivité chimique et propriétés biologiques dans la série de l'aminochlorambucil [Chemical reactivity and biological properties of a series of aminochlorambucil derivatives]. C R Acad Hebd Seances Acad Sci D. 1978 Mar 20;286(11):905-7. French. PMID: 96958.

2: Dunn CD, Elson LA. The comparative effect of busulphan ('Myleran') and aminochlorambucil on haemopoietic colony forming units in the rat. Cell Tissue Kinet. 1970 Apr;3(2):131-41. doi: 10.1111/j.1365-2184.1970.tb00260.x. PMID: 4942743.

3: CREE IC, HALLENBECK GA, SHORTER RG. INEFFECTIVENESS OF AMINOCHLORAMBUCIL IN DELAYING REJECTION OF CANINE RENAL HOMOGRAFTS. Transplantation. 1965 May;3:451-2. doi: 10.1097/00007890-196505000-00015. PMID: 14285097.

4: FLOERSHEIM GL, ELSON LA. [Restoration of hematopoiesis following a lethal dose of dimethyl myleran by isologic bone marrow transplantation in mice. Experiments on modification of intolerance to homologous bone marrow by 6-mercaptopurine, aminochlorambucil and cortisone]. Acta Haematol. 1961;26:233-45. German. doi: 10.1159/000206657. PMID: 13893617.