CGS-35066
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574624

CAS#: 261619-50-5

Description: CGS-35066 is an endothelin-converting enzyme (ECE) inhibitor that blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).

Chemical Structure

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CGS-35066
CAS# 261619-50-5
Instruction

Theoretical Analysis

MedKoo Cat#: 574624
Name: CGS-35066
CAS#: 261619-50-5
Chemical Formula: C16H16NO6P
Exact Mass: 349.07
Molecular Weight: 349.280
Elemental Analysis: C, 55.02; H, 4.62; N, 4.01; O, 27.48; P, 8.87

Price and Availability

Size Price Availability Quantity
10mg USD 465 2 Weeks
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Synonym: CGS 35066; CGS-35066; CGS35066

IUPAC/Chemical Name: α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid

InChi Key: CRUVAUSVWLATAE-ZDUSSCGKSA-N

InChi Code: InChI=1S/C16H16NO6P/c18-16(19)13(17-9-24(20,21)22)7-10-5-6-12-11-3-1-2-4-14(11)23-15(12)8-10/h1-6,8,13,17H,7,9H2,(H,18,19)(H2,20,21,22)/t13-/m0/s1

SMILES Code: O=C(O)[C@@H](NCP(O)(O)=O)CC1=CC=C2C(OC3=CC=CC=C23)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 349.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. De Lombaert et al (2000) Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action. J.Med.Chem. 43 488 PMID: 10669576

2. Trapani et al (2000) Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats. J.Cardiovasc.Pharmacol. 36 S40 PMID: 11078331

3. Kwan et al (2002) Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor. Neuropharmacol.Neurotoxicol. 13 197