Lysine hydroxamate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530752

CAS#: 25125-92-2

Description: Lysine hydroxamate is a bioactive chemical.

Chemical Structure

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Lysine hydroxamate
CAS# 25125-92-2
Instruction

Theoretical Analysis

MedKoo Cat#: 530752
Name: Lysine hydroxamate
CAS#: 25125-92-2
Chemical Formula: C6H15N3O2
Exact Mass: 161.12
Molecular Weight: 161.205
Elemental Analysis: C, 44.70; H, 9.38; N, 26.07; O, 19.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Lysine hydroxamate

IUPAC/Chemical Name: Hexanamide, 2,6-diamino-N-hydroxy-, (S)-

InChi Key: NZWPVDFOIUKVSJ-YFKPBYRVSA-N

InChi Code: InChI=1S/C6H15N3O2/c7-4-2-1-3-5(8)6(10)9-11/h5,11H,1-4,7-8H2,(H,9,10)/t5-/m0/s1

SMILES Code: O=C(NO)[C@@H](N)CCCCN

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 161.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sakurama H, Takita T, Mikami B, Itoh T, Yasukawa K, Inouye K. Two crystal structures of lysyl-tRNA synthetase from Bacillus stearothermophilus in complex with lysyladenylate-like compounds: insights into the irreversible formation of the enzyme-bound adenylate of L-lysine hydroxamate. J Biochem. 2009 May;145(5):555-63. doi: 10.1093/jb/mvp014. Epub 2009 Jan 27. PubMed PMID: 19174549.

2: Wirgau JI, Spasojević I, Boukhalfa H, Batinić-Haberle I, Crumbliss AL. Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid. Inorg Chem. 2002 Mar 25;41(6):1464-73. PubMed PMID: 11896715.

3: Takita T, Akita E, Inouye K, Tonomura B. Lysyl-tRNA synthetase from Bacillus stearothermophilus. Stopped-flow kinetic analysis of enzyme.lysyladenylate formation. J Biochem. 1998 Jul;124(1):45-50. PubMed PMID: 9644244.

4: Kyriacou A, Balis C, Typas MA. Improvement of lysine production by analog-sensitive and auxotroph mutants of the acetylene-utilizing bacterium Gordona bronchialis (Rhodococcus bronchialis). Appl Biochem Biotechnol. 1997 Jun;66(3):281-9. PubMed PMID: 9276926.

5: Takita T, Hashimoto S, Ohkubo Y, Muto T, Shimizu N, Sukata T, Inouye K, Hiromi K, Tonomura B. Lysyl-tRNA synthetase from Bacillus stearothermophilus. Formation and isolation of an enzyme-lysyladenylate complex and its analogue. J Biochem. 1997 Feb;121(2):244-50. PubMed PMID: 9089397.

6: Barak Z, Lindsley D, Gallant J. On the mechanism of leftward frameshifting at several hungry codons. J Mol Biol. 1996 Mar 8;256(4):676-84. PubMed PMID: 8642590.

7: al-Swayeh OA, Moore PK. Amino acids dilate resistance blood vessels of the perfused rat mesentery. J Pharm Pharmacol. 1989 Oct;41(10):723-6. PubMed PMID: 2575155.

8: Lunts MG, Gusiatiner MM, Kopteva AV, Zhdanova NI. [Characteristics of lysine transport in a wild type strain and lysine-producing mutant of Corynebacterium glutamicum]. Prikl Biokhim Mikrobiol. 1986 Jan-Feb;22(1):96-101. Russian. PubMed PMID: 3081884.

9: Hilderman RH, Zimmerman JK, Dang CV, Grothusen JR. Characterization of a homogeneous arginyl- and lysyl-tRNA synthetase complex isolated from rat liver. Kinetic mechanism for lysyl-tRNA synthetase. J Biol Chem. 1983 Nov 25;258(22):13592-6. PubMed PMID: 6315704.

10: Mehta RJ, Nash CH. Relationship between carbon source and susceptibility of Cephalosporium acremonium to selected amino acid analogues. Can J Microbiol. 1979 Jul;25(7):818-21. PubMed PMID: 573170.

11: Tosa T, Pizer LI. Effect of serine hydroxamate on the growth of Escherichia coli. J Bacteriol. 1971 Jun;106(3):966-71. PubMed PMID: 4934071; PubMed Central PMCID: PMC248739.