Brodifacoum | CAS#56073-10-0 | vitamin K antagonist anticoagulant |MedKoo

Brodifacoum
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584165

CAS#: 56073-10-0

Description: Brodifacoum is a highly lethal 4-hydroxycoumarin vitamin K antagonist anticoagulant poison. In recent years, it has become one of the world's most widely used pesticides. It is typically used as a rodenticide but is also used to control larger pests such as possum. Brodifacoum has an especially long half-life in the body, which ranges to several months, requiring prolonged treatment with antidotal vitamin K for both human and pet poisonings. It has one of the highest risks of secondary poisoning to both mammals and birds.

Chemical Structure

Brodifacoum

CAS# 56073-10-0

Instruction

Theoretical Analysis

MedKoo Cat#: 584165
Name: Brodifacoum
CAS#: 56073-10-0
Chemical Formula: C31H23BrO3
Exact Mass: 522.08
Molecular Weight: 523.426
Elemental Analysis: C, 71.14; H, 4.43; Br, 15.27; O, 9.17

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 450	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Brodifakum; Bromfenacoum; Klerat; PP 581; Ratak; Super warfarin; Talon; Volid; WBA 8119;

IUPAC/Chemical Name: 2H-1-Benzopyran-2-one, 3-(3-(4'-bromo(1,1'-biphenyl)-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl)-4-hydroxy-

InChi Key: VEUZZDOCACZPRY-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H23BrO3/c32-24-15-13-20(14-16-24)19-9-11-21(12-10-19)23-17-22-5-1-2-6-25(22)27(18-23)29-30(33)26-7-3-4-8-28(26)35-31(29)34/h1-16,23,27,33H,17-18H2

SMILES Code: O=C1C(C2CC(C3=CC=C(C4=CC=C(Br)C=C4)C=C3)CC5=C2C=CC=C5)=C(O)C6=CC=CC=C6O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 523.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yan H, Zhuo XY, Shen BH, Xiang P, Shen M. [Evaluation of Brodifacoum-induced Toxicity by Metabonomics Approach Based on HPLC-TOF-MS]. Fa Yi Xue Za Zhi. 2017 Jun;33(3):247-251. doi: 10.3969/j.issn.1004-5619.2017.03.007. Epub 2017 Jun 25. Chinese. PubMed PMID: 29230988.

2: Fitzgerald SD, Martinez J, Buchweitz JP. An apparent case of brodifacoum toxicosis in a whelping dog. J Vet Diagn Invest. 2018 Jan;30(1):169-171. doi: 10.1177/1040638717741664. Epub 2017 Nov 16. PubMed PMID: 29145778.

3: Parton KH, Willson EK, Collett MG, Booth LH. Recovery of brodifacoum in vomitus following induction of emesis in dogs that had ingested rodenticide bait. N Z Vet J. 2018 Jan;66(1):41-43. doi: 10.1080/00480169.2017.1379915. Epub 2017 Oct 11. PubMed PMID: 28920541.

4: Kalinin S, Marangoni N, Kowal K, Dey A, Lis K, Brodsky S, van Breemen R, Hauck Z, Ripper R, Rubinstein I, Weinberg G, Feinstein DL. The Long-Lasting Rodenticide Brodifacoum Induces Neuropathology in Adult Male Rats. Toxicol Sci. 2017 Sep 1;159(1):224-237. doi: 10.1093/toxsci/kfx134. PubMed PMID: 28903499.

5: Alomar H, Chabert A, Coeurdassier M, Vey D, Berny P. Accumulation of anticoagulant rodenticides (chlorophacinone, bromadiolone and brodifacoum) in a non-target invertebrate, the slug, Deroceras reticulatum. Sci Total Environ. 2018 Jan 1;610-611:576-582. doi: 10.1016/j.scitotenv.2017.08.117. Epub 2017 Aug 17. PubMed PMID: 28822925.

6: Deng Y, Qiu L. Therapeutic plasma exchange: a second-line treatment for brodifacoum poisoning following an anaphylactoid reaction to vitamin K. Clin Case Rep. 2016 Dec 18;5(1):35-38. doi: 10.1002/ccr3.756. eCollection 2017 Jan. PubMed PMID: 28096987; PubMed Central PMCID: PMC5224774.

7: Feinstein DL, Brodsky S, Weinberg G, van Breeman R, Rubinstein I. Brodifacoum poisoning: A clear and present danger to public health in the USA. Toxicol Lett. 2017 Feb 15;268:71-72. doi: 10.1016/j.toxlet.2017.01.004. Epub 2017 Jan 11. PubMed PMID: 28088390.

8: Justice-Allen A, Loyd KA. Mortality of Western Burrowing Owls ( Athene cunicularia hypugaea) Associated with Brodifacoum Exposure. J Wildl Dis. 2017 Jan;53(1):165-169. doi: 10.7589/2015-12-321. Epub 2016 Oct 20. PubMed PMID: 27763828.

9: Gül N, Yiğit N, Saygılı F, Demirel E, Geniş C. Comparison of the effects of difenacoum and brodifacoum on the ultrastructure of rat liver cells. Arh Hig Rada Toksikol. 2016 Sep 1;67(3):204-209. doi: 10.1515/aiht-2016-67-2783. PubMed PMID: 27749259.

10: Yan H, Qiao Z, Shen B, Xiang P, Shen M. Plasma metabolic profiling analysis of toxicity induced by brodifacoum using metabonomics coupled with multivariate data analysis. Forensic Sci Int. 2016 Oct;267:129-135. doi: 10.1016/j.forsciint.2016.08.027. Epub 2016 Aug 28. PubMed PMID: 27598867.

11: Anderson SL, Kattappuram RS, Marrs JC, Joseph NM. Intentional Brodifacoum Ingestion. Am J Med. 2017 Jan;130(1):e27-e28. doi: 10.1016/j.amjmed.2016.08.010. Epub 2016 Aug 31. PubMed PMID: 27591180.

12: Hauck ZZ, Feinstein DL, van Breemen RB. LC-MS-MS Analysis of Brodifacoum Isomers in Rat Tissue. J Anal Toxicol. 2016 May;40(4):304-9. doi: 10.1093/jat/bkw008. Epub 2016 Feb 23. PubMed PMID: 26912564; PubMed Central PMCID: PMC4834430.

13: Booth GS, Mody PZ. Brodifacoum Inhalation and its Clinical Manifestations in a 21-Year-Old Caucasian Man. Lab Med. 2016 Feb;47(1):63-6. doi: 10.1093/labmed/lmv008. Epub 2015 Dec 29. PubMed PMID: 26715613.

14: Wang Y, Kotik V, Fahim G, Alagusundaramoorthy S, Eltawansy SA, Mathis S, Saleh J. Treatment of brodifacoum overdose with prothrombin complex concentrate. Am J Health Syst Pharm. 2016 Jan 1;73(1):e14-7. doi: 10.2146/ajhp150233. PubMed PMID: 26683673.

15: Ware KM, Feinstein DL, Rubinstein I, Weinberg G, Rovin BH, Hebert L, Muni N, Cianciolo RE, Satoskar AA, Nadasdy T, Brodsky SV. Brodifacoum induces early hemoglobinuria and late hematuria in rats: novel rapid biomarkers of poisoning. Am J Nephrol. 2015;41(4-5):392-9. doi: 10.1159/000433568. Epub 2015 Jun 20. PubMed PMID: 26111556; PubMed Central PMCID: PMC4514561.

16: Webster KH, Harr KE, Bennett DC, Williams TD, Cheng KM, Maisonneuve F, Elliott JE. Assessment of toxicity and coagulopathy of brodifacoum in Japanese quail and testing in wild owls. Ecotoxicology. 2015 Jul;24(5):1087-101. doi: 10.1007/s10646-015-1449-1. Epub 2015 Apr 1. PubMed PMID: 25827684.

17: Masuda BM, Fisher P, Beaven B. Residue profiles of brodifacoum in coastal marine species following an island rodent eradication. Ecotoxicol Environ Saf. 2015 Mar;113:1-8. doi: 10.1016/j.ecoenv.2014.11.013. Epub 2014 Nov 28. PubMed PMID: 25437099.

18: Geduhn A, Esther A, Schenke D, Mattes H, Jacob J. Spatial and temporal exposure patterns in non-target small mammals during brodifacoum rat control. Sci Total Environ. 2014 Oct 15;496:328-338. doi: 10.1016/j.scitotenv.2014.07.049. Epub 2014 Aug 1. PubMed PMID: 25087064.

19: Lee HJ, You MR, Moon WR, Sul H, Chung CH, Park CY, Park SG. Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum. Korean J Intern Med. 2014 Jul;29(4):498-508. doi: 10.3904/kjim.2014.29.4.498. Epub 2014 Jun 27. PubMed PMID: 25045298; PubMed Central PMCID: PMC4101597.

20: Underwood EL, Sutton J, Ellis IK, Qualls B, Zamber J, Walker BN. Prolonged coagulopathy after brodifacoum exposure. Am J Health Syst Pharm. 2014 Apr 15;71(8):639-42. doi: 10.2146/ajhp130537. PubMed PMID: 24688037.

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