CBBR
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561751

CAS#: 6104-59-2

Description: CBBR is an inhibitor of wild type and mutant alpha-synuclein aggregation and a modulator of neurotoxicity. It is also used as a protein staining dye.

Chemical Structure

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CBBR
CAS# 6104-59-2
Instruction

Theoretical Analysis

MedKoo Cat#: 561751
Name: CBBR
CAS#: 6104-59-2
Chemical Formula: C45H44N3NaO7S2
Exact Mass: 0.00
Molecular Weight: 825.970
Elemental Analysis: C, 65.44; H, 5.37; N, 5.09; Na, 2.78; O, 13.56; S, 7.76

Price and Availability

Size Price Availability Quantity
5g USD 250 2 Weeks
10g USD 350 2 Weeks
25g USD 550 2 Weeks
Bulk inquiry

Synonym: CBBR; Coomassie Brilliant Blue R; Coomassie Brilliant Blue R250; Brilliant Blue R; Acid Blue 83;

IUPAC/Chemical Name: Sodium 3-[[4-[[4-(4-ethoxyanilino)phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]cyclohexa-2,5-dien-1-ylidene]methyl]-N-ethylanilino]methyl]benzenesulfonate

InChi Key: NKLPQNGYXWVELD-UHFFFAOYSA-M

InChi Code: InChI=1S/C45H45N3O7S2.Na/c1-4-47(31-33-9-7-11-43(29-33)56(49,50)51)40-23-15-36(16-24-40)45(35-13-19-38(20-14-35)46-39-21-27-42(28-22-39)55-6-3)37-17-25-41(26-18-37)48(5-2)32-34-10-8-12-44(30-34)57(52,53)54;/h7-30H,4-6,31-32H2,1-3H3,(H2,49,50,51,52,53,54);/q;+1/p-1

SMILES Code: O=S(C1=CC=CC(CN(CC)C2=CC=C(/C(C3=CC=C(NC4=CC=C(OCC)C=C4)C=C3)=C5C=C/C(C=C\5)=[N+](CC)\CC6=CC=CC(S(=O)([O-])=O)=C6)C=C2)=C1)([O-])=O.[Na+]

Appearance: Solid powder

Purity: >93% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 825.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ahsan N, Siddique IA, Gupta S, Surolia A. A routinely used protein staining dye acts as an inhibitor of wild type and mutant alpha-synuclein aggregation and modulator of neurotoxicity. Eur J Med Chem. 2018 Jan 1;143:1174-1184. doi: 10.1016/j.ejmech.2017.10.002. Epub 2017 Oct 12. PubMed PMID: 29150334.

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