BTT-3033
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555105

CAS#: 1259028-99-3

Description: BTT-3033 is a α2β1 integrin inhibitor. BTT-3033 blocks platelet attachment under flow (90 dynes/cm(2)). The action of BTT-3033, unlike that of BTT-3034, was dependent on Tyr-285.

Chemical Structure

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BTT-3033
CAS# 1259028-99-3
Instruction

Theoretical Analysis

MedKoo Cat#: 555105
Name: BTT-3033
CAS#: 1259028-99-3
Chemical Formula: C23H20FN5O3S
Exact Mass: 465.13
Molecular Weight: 465.503
Elemental Analysis: C, 59.35; H, 4.33; F, 4.08; N, 15.05; O, 10.31; S, 6.89

Price and Availability

Size Price Availability Quantity
50mg USD 550 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2850 2 Weeks
1g USD 3850 2 Weeks
2g USD 5950 2 Weeks
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Synonym: BTT-3033; BTT 3033; BTT3033.

IUPAC/Chemical Name: 1-(4-Fluorophenyl)-N-methyl-N-(4-(3-phenylureido)phenyl)-1H-pyrazole-4-sulfonamide

InChi Key: NSLIQOPYDUKWTA-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H20FN5O3S/c1-28(33(31,32)22-15-25-29(16-22)21-11-7-17(24)8-12-21)20-13-9-19(10-14-20)27-23(30)26-18-5-3-2-4-6-18/h2-16H,1H3,(H2,26,27,30)

SMILES Code: O=S(C1=CN(C2=CC=C(F)C=C2)N=C1)(N(C)C3=CC=C(NC(NC4=CC=CC=C4)=O)C=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: The interaction between α2β1 integrin (GPIa/IIa, VLA-2) and vascular collagen is one of the initiating events in thrombus formatio

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 465.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nissinen L, Koivunen J, Käpylä J, Salmela M, Nieminen J, Jokinen J, Sipilä K,
Pihlavisto M, Pentikäinen OT, Marjamäki A, Heino J. Novel α2β1 integrin
inhibitors reveal that integrin binding to collagen under shear stress conditions
does not require receptor preactivation. J Biol Chem. 2012 Dec
28;287(53):44694-702. doi: 10.1074/jbc.M111.309450. Epub 2012 Nov 6. PubMed PMID:
23132859; PubMed Central PMCID: PMC3531784.