Quadrosilan

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206925

CAS#: 4657-20-9

Description: Quadrosilan, also known as Cisobitan and KABI-1774, is a synthetic, nonsteroidal estrogen that was developed in the 1970s and that is or has been used as an antigonadotropic agent in the treatment of prostate cancer. It is an organosilicon compound, and is also known as 2,6-cisdiphenylhexamethylcyclotetrasiloxane. Quadrosilan has estrogenic activity equivalent to that of estradiol, and can produce feminization and gynecomastia as side effects in male patients.

Chemical Structure

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Quadrosilan
CAS# 4657-20-9
Instruction

Theoretical Analysis

MedKoo Cat#: 206925
Name: Quadrosilan
CAS#: 4657-20-9
Chemical Formula: C18H28O4Si4
Exact Mass: 420.11
Molecular Weight: 420.758
Elemental Analysis: C, 51.38; H, 6.71; O, 15.21; Si, 26.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Quadrosilan, Cisobitan; KABI-1774; KABI 1774; KABI1774.

IUPAC/Chemical Name: 2,2,4,6,6,8-hexamethyl-4,8-diphenyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane

InChi Key: ZTQZMPQJXABFNC-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H28O4Si4/c1-23(2)19-25(5,17-13-9-7-10-14-17)21-24(3,4)22-26(6,20-23)18-15-11-8-12-16-18/h7-16H,1-6H3

SMILES Code: C[Si]1(C2=CC=CC=C2)O[Si](C)(C)O[Si](C3=CC=CC=C3)(C)O[Si](C)(C)O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 420.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Alfthan O, Andersson L, Esposti PL, Fosså SD, Gammelgaard PA, Gjöres JE, Isacson S, Rasmussen F, Ruutu M, von Schreeb T, Setterberg G, Strandell P, Strindberg B. Cisobitan in treatment of prostatic cancer. A prospective controlled multicentre study. Scand J Urol Nephrol. 1983;17(1):37-43. PubMed PMID: 6346476.

2: Collste L, Berlin T, von Garrelts B, Granberg I, Lewander R. Clinical trial of a new antigonadotropic substance, 2,6-cis-diphenylhexamethylcyclotetrasiloxane, in cancer of the prostate. A pilot study. Eur Urol. 1981;7(2):85-8. PubMed PMID: 7461008.

3: Sundwall A. Cisobitan--a new drug with anti-gonadotropic and anti-androgenic properties. Pharmacological effects. Scand J Urol Nephrol Suppl. 1980;55:121-5. PubMed PMID: 6938014.

4: Albanus L, Björklund NE, Gustafsson B, Jönsson M. Forty days oral toxicity of 2,6-cis-diphenylhexamethylcyclotetrasiloxane (KABI 1774)in beagle dogs with special reference to effects on the male reproductive system. Acta Pharmacol Toxicol (Copenh). 1975;36(Suppl 3):93-130. PubMed PMID: 1080338.

5: Nicander L. Changes produced in the male genital organs of rabbits and dogs by 2,6-cis-diphenylhexamethylcyclotetrasiloxane (KABI 1774). Acta Pharmacol Toxicol (Copenh). 1975;36(Suppl 3):40-54. PubMed PMID: 1080333.

6: Schmiterlöw CG, Sjögren C. The distribution of 14-C labelled KABI 1774. Acta Pharmacol Toxicol (Copenh). 1975;36(Suppl 3):131-8. PubMed PMID: 1080328.

7: Nicander L. The effects on the male genital organs and dogs of a new antifertility compound KABI 1774. J Reprod Fertil. 1972 Dec;31(3):517-8. PubMed PMID: 4653473.