GNF179
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530934

CAS#: 1261114-01-5

Description: GNF179 is an antiparasitic drug.


Price and Availability

Size
Price

50mg
USD 250
500mg
USD 1450
5g
USD 5950
Size
Price

100mg
USD 450
1g
USD 2150
Size
Price

200mg
USD 750
2g
USD 3850

GNF179, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530934
Name: GNF179
CAS#: 1261114-01-5
Chemical Formula: C22H23ClFN5O
Exact Mass: 427.1575
Molecular Weight: 427.9084
Elemental Analysis: C, 61.75; H, 5.42; Cl, 8.28; F, 4.44; N, 16.37; O, 3.74


Synonym: GNF179; GNF-179; GNF 179.

IUPAC/Chemical Name: 2-amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethanone

InChi Key: KFSKTWYDIHJITF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H23ClFN5O/c1-22(2)21-27-19(14-3-7-16(24)8-4-14)20(26-17-9-5-15(23)6-10-17)28(21)11-12-29(22)18(30)13-25/h3-10,26H,11-13,25H2,1-2H3

SMILES Code: CC1(C)C2=NC(C3=CC=C(F)C=C3)=C(NC4=CC=C(Cl)C=C4)N2CCN1C(CN)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Meister S, Plouffe DM, Kuhen KL, Bonamy GM, Wu T, Barnes SW, Bopp SE, Borboa
R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P,
Groessl T, Kato N, Lee MC, McNamara CW, Fidock DA, Nagle A, Nam TG, Richmond W,
Roland J, Rottmann M, Zhou B, Froissard P, Glynne RJ, Mazier D, Sattabongkot J,
Schultz PG, Tuntland T, Walker JR, Zhou Y, Chatterjee A, Diagana TT, Winzeler EA.
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug
discovery. Science. 2011 Dec 9;334(6061):1372-7. doi: 10.1126/science.1211936.
Epub 2011 Nov 17. PubMed PMID: 22096101; PubMed Central PMCID: PMC3473092.

2: Magistrado PA, Corey VC, Lukens AK, LaMonte G, Sasaki E, Meister S, Wree M,
Winzeler E, Wirth DF. Plasmodium falciparum Cyclic Amine Resistance Locus
(PfCARL), a Resistance Mechanism for Two Distinct Compound Classes. ACS Infect
Dis. 2016 Nov 11;2(11):816-826. Epub 2016 Apr 7. PubMed PMID: 27933786; PubMed
Central PMCID: PMC5109296.

3: Lim MY, LaMonte G, Lee MC, Reimer C, Tan BH, Corey V, Tjahjadi BF, Chua A,
Nachon M, Wintjens R, Gedeck P, Malleret B, Renia L, Bonamy GM, Ho PC, Yeung BK,
Chow ED, Lim L, Fidock DA, Diagana TT, Winzeler EA, Bifani P. UDP-galactose and
acetyl-CoA transporters as Plasmodium multidrug resistance genes. Nat Microbiol.
2016 Sep 19:16166. doi: 10.1038/nmicrobiol.2016.166. [Epub ahead of print] PubMed
PMID: 27642791; PubMed Central PMCID: PMC5575994.