PF-05241328
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MedKoo CAT#: 530927

CAS#: 1387633-03-5

Description: PF-05241328 is a potent and selective inhibitor of Human Nav1.7 Voltage-Dependent Sodium Channel. PF-05089771 provided the best opportunity to explore Nav1.7 blockade for the treatment of acute or chronic pain conditions.


Price and Availability

Size
Price

1g
USD 3750
Size
Price

2g
USD 6750
Size
Price

5g
Ask price

PF-05241328, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530927
Name: PF-05241328
CAS#: 1387633-03-5
Chemical Formula: C19H21ClN4O4S
Exact Mass: 436.0972
Molecular Weight: 436.911
Elemental Analysis: C, 52.23; H, 4.84; Cl, 8.11; N, 12.82; O, 14.65; S, 7.34


Synonym: PF-05241328; PF 05241328; PF05241328; PF-5241328; PF 5241328; PF5241328.

IUPAC/Chemical Name: 1-(5-Chloro-6-(2-methylpropoxy)-3-pyridinyl)-3-methyl-N-(methylsulfonyl)-1H-indazole-5-carboxamide

InChi Key: RVTSXVZXEGFIPW-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21ClN4O4S/c1-11(2)10-28-19-16(20)8-14(9-21-19)24-17-6-5-13(7-15(17)12(3)22-24)18(25)23-29(4,26)27/h5-9,11H,10H2,1-4H3,(H,23,25)

SMILES Code: O=C(C1=CC2=C(N(C3=CC(Cl)=C(OCC(C)C)N=C3)N=C2C)C=C1)NS(=O)(C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

The emergence of genetic data linking Nav1.7 sodium channel over- and under- expression to human pain signalling has led to an interest in the treatment of chronic pain through inhibition of Nav1.7 channels.


References

1: Jones HM, Butt RP, Webster RW, Gurrell I, Dzygiel P, Flanagan N, Fraier D, Hay
T, Iavarone LE, Luckwell J, Pearce H, Phipps A, Segelbacher J, Speed B, Beaumont
K. Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four
Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels. Clin
Pharmacokinet. 2016 Jul;55(7):875-87. doi: 10.1007/s40262-015-0365-0. PubMed
PMID: 26895021.