WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530919
Description: ML-030, also known as CID-11757146, is a potent and selective PDE4 inhibitor. ML-030 inhibits PDE4 in a cell-based cyclic nucleotide-gated cation channel biosensor assay with an EC50 value of 18.7 nM.
MedKoo Cat#: 530919
Chemical Formula: C20H20N4O4S
Exact Mass: 412.1205
Molecular Weight: 412.464
Elemental Analysis: C, 58.24; H, 4.89; N, 13.58; O, 15.52; S, 7.77
Synonym: ML-030; ML 030; ML030; CID-11757146; CID 11757146; CID11757146.
IUPAC/Chemical Name: 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine
InChi Key: DZAUSKKPHXFGNN-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H20N4O4S/c1-25-13-6-8-16(26-2)14(10-13)19-21-22-20-24(19)23-15(11-29-20)12-5-7-17(27-3)18(9-12)28-4/h5-10H,11H2,1-4H3
SMILES Code: COC1=CC=C(C2=NN3C(SC2)=NN=C3C4=CC(OC)=CC=C4OC)C=C1OC
Type 4 cyclic nucleotide phosphodiesterases (PDE4s), which are highly expressed in neutrophils and monocytes, selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP.