RO10-5824
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530904

CAS#: 189744-46-5

Description: RO10-5824 is a D4-selective partial agonist. RO10-5824 is a potent candidate for the management of cocaine use disorders. The identification of effective medications for the management of cocaine use disorders remains an unmet public health challenge. In view of the prominent role of dopaminergic mechanisms in cocaine's abuse-related effects, research has focused on the development of subtype-selective dopamine D1-4 receptor antagonists.


Price and Availability

Size
Price

100mg
USD 1350
1g
USD 3450
Size
Price

200mg
USD 1850
2g
USD 4850
Size
Price

500mg
USD 2650

Ro 10-5824, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530904
Name: RO10-5824
CAS#: 189744-46-5
Chemical Formula: C17H20N4
Exact Mass: 280.1688
Molecular Weight: 280.375
Elemental Analysis: C, 72.83; H, 7.19; N, 19.98


Synonym: RO10-5824; RO 10-5824; RO-10-5824; RO105824; RO 105824; RO-105824.

IUPAC/Chemical Name: 2-methyl-5-((4-phenyl-5,6-dihydropyridin-1(2H)-yl)methyl)pyrimidin-4-amine

InChi Key: KABDATZAOUSYES-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20N4/c1-13-19-11-16(17(18)20-13)12-21-9-7-15(8-10-21)14-5-3-2-4-6-14/h2-7,11H,8-10,12H2,1H3,(H2,18,19,20)

SMILES Code: NC1=NC(C)=NC=C1CN2CC=C(C3=CC=CC=C3)CC2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bergman J, Rheingold CG. Dopamine D₄ Receptor Antagonists for the Treatment of
Cocaine Use Disorders. CNS Neurol Disord Drug Targets. 2015;14(6):707-15. Review.
PubMed PMID: 26022267.

2: Murai T, Nakako T, Ikeda K, Ikejiri M, Ishiyama T, Taiji M. Lack of dopamine
D4 receptor affinity contributes to the procognitive effect of lurasidone. Behav
Brain Res. 2014 Mar 15;261:26-30. doi: 10.1016/j.bbr.2013.11.036. Epub 2013 Dec
1. PubMed PMID: 24304719.