PE859
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MedKoo CAT#: 530903

CAS#: 1402727-29-0

Description: PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. PE859 inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8. PE859 reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo.


Price and Availability

Size
Price

100mg
USD 1450
1g
USD 3650
Size
Price

200mg
USD 1850
2g
USD 4950
Size
Price

500mg
USD 2750

PE859, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530903
Name: PE859
CAS#: 1402727-29-0
Chemical Formula: C28H24N4O2
Exact Mass: 448.1899
Molecular Weight: 448.526
Elemental Analysis: C, 74.98; H, 5.39; N, 12.49; O, 7.13


Synonym: PE859; PE-859; PE 859.

IUPAC/Chemical Name: 6-((E)-2-(5-((E)-2-methoxy-4-(pyridin-2-ylmethoxy)styryl)-1H-pyrazol-3-yl)vinyl)-1H-indole

InChi Key: AMBZHNVCLPHAKA-NSJFVGFPSA-N

InChi Code: InChI=1S/C28H24N4O2/c1-33-28-18-26(34-19-25-4-2-3-14-29-25)12-9-22(28)8-11-24-17-23(31-32-24)10-6-20-5-7-21-13-15-30-27(21)16-20/h2-18,30H,19H2,1H3,(H,31,32)/b10-6+,11-8+

SMILES Code: COC1=CC(OCC2=NC=CC=C2)=CC=C1/C=C/C3=CC(/C=C/C4=CC5=C(C=C4)C=CN5)=NN3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Okuda M, Fujita Y, Hijikuro I, Wada M, Uemura T, Kobayashi Y, Waku T, Tanaka
N, Nishimoto T, Izumi Y, Kume T, Akaike A, Takahashi T, Sugimoto H. PE859, A
Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and
Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8. J
Alzheimers Dis. 2017;59(1):313-328. doi: 10.3233/JAD-161017. PubMed PMID:
28598836.

2: Okuda M, Hijikuro I, Fujita Y, Teruya T, Kawakami H, Takahashi T, Sugimoto H.
Design and synthesis of curcumin derivatives as tau and amyloid β dual
aggregation inhibitors. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5024-5028. doi:
10.1016/j.bmcl.2016.08.092. Epub 2016 Aug 31. PubMed PMID: 27624076.

3: Okuda M, Hijikuro I, Fujita Y, Wu X, Nakayama S, Sakata Y, Noguchi Y, Ogo M,
Akasofu S, Ito Y, Soeda Y, Tsuchiya N, Tanaka N, Takahashi T, Sugimoto H. PE859,
a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and
progression of neural dysfunction in vivo. PLoS One. 2015 Feb 6;10(2):e0117511.
doi: 10.1371/journal.pone.0117511. eCollection 2015. PubMed PMID: 25659102;
PubMed Central PMCID: PMC4319983.