163-BP3

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561347

CAS#: Unknown

Description: 163-BP3 is a potent photoaffinity probe that targets gamma-secretase. Gamma-secretase is a multiprotein complex that catalyzes intramembrane proteolysis associated with Alzheimer's disease and cancer.


Price and Availability

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163-BP3 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561347
Name: 163-BP3
CAS#: Unknown
Chemical Formula: C28H25F3N2O5S
Exact Mass: 558.1436
Molecular Weight: 558.57
Elemental Analysis: C, 60.21; H, 4.51; F, 10.20; N, 5.02; O, 14.32; S, 5.74


Synonym: 163-BP3; 163 BP3; 163BP3;

IUPAC/Chemical Name: (R)-5,5,5-trifluoro-2-(N-(4-(4-(prop-2-yn-1-yloxy)benzoyl)benzyl)phenylsulfonamido)pentanamide

InChi Key: ITJWFVOVZQGYOY-RUZDIDTESA-N

InChi Code: InChI=1S/C28H25F3N2O5S/c1-2-18-38-23-14-12-22(13-15-23)26(34)21-10-8-20(9-11-21)19-33(25(27(32)35)16-17-28(29,30)31)39(36,37)24-6-4-3-5-7-24/h1,3-15,25H,16-19H2,(H2,32,35)/t25-/m1/s1

SMILES Code: FC(CC[C@H](C(N)=O)N(S(=O)(C1=CC=CC=C1)=O)CC2=CC=C(C(C3=CC=C(OCC#C)C=C3)=O)C=C2)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Crump CJ, Murrey HE, Ballard TE, Am Ende CW, Wu X, Gertsik N, Johnson DS, Li YM. Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase. ACS Chem Neurosci. 2016 Aug 17;7(8):1166-73. doi: 10.1021/acschemneuro.6b00127. Epub 2016 Jun 17. PubMed PMID: 27253220.