Hispidulin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561302

CAS#: 1447-88-7

Description: Hispidulin, also known as Dinatin, is a naturally occurring flavone with potential antiepileptic activity in rats and gerbils. It is found in plants including Grindelia argentina, Arrabidaea chica, Saussurea involucrate, Crossostephium chinense, Artemisia, and Salvia. Hispidulin is an activator of AMP-activated protein kinase (AMPK) and inhibits the release of glutamate and methamphetamine-induced hyperlocomotion (MIH).


Price and Availability

Size
Price

5mg
USD 250
Size
Price

25mg
USD 650
Size
Price

Hispidulin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561302
Name: Hispidulin
CAS#: 1447-88-7
Chemical Formula: C16H12O6
Exact Mass: 300.0634
Molecular Weight: 300.27
Elemental Analysis: C, 64.00; H, 4.03; O, 31.97


Synonym: Hispidulin; Dinatin; NSC-122415; NSC 122415; NSC122415;

IUPAC/Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one

InChi Key: IHFBPDAQLQOCBX-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3

SMILES Code: O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=C(OC)C(O)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Patel K, Patel DK. Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report. J Tradit Complement Med. 2016 Dec 10;7(3):360-366. doi: 10.1016/j.jtcme.2016.11.003. eCollection 2017 Jul. Review. PubMed PMID: 28725632; PubMed Central PMCID: PMC5506639.

2: Atif M, Ali I, Hussain A, Hyder Sv, Khan FA, Maalik A, Farooq U. PHARMACOLOGICAL ASSESSMENT OF HISPIDULIN - A NATURAL BIOACTIVE FLAVONE. Acta Pol Pharm. 2016 May-Jun;73(3):565-78. Review. PubMed PMID: 27476273.

3: Zhang L, Wei K, Xu J, Yang D, Zhang C, Wang Z, Li M. Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review. J Ethnopharmacol. 2016 Jun 20;186:1-13. doi: 10.1016/j.jep.2016.03.046. Epub 2016 Mar 23. Review. PubMed PMID: 27032710.

4: Atif M, Ali I, Hussain A, Hyder SV, Niaz B, Khan FA, Maalik A, Farooq U. PHARMACOLOGICAL ASSESSMENT OF HISPIDULIN--A NATURAL BIOACTIVE FLAVONE. Acta Pol Pharm. 2015 Sep-Oct;72(5):829-42. Review. PubMed PMID: 26665389.

5: Moufid A, Eddouks M. Artemisia herba alba: a popular plant with potential medicinal properties. Pak J Biol Sci. 2012 Dec 15;15(24):1152-9. Review. PubMed PMID: 23755405.