1D-2

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561264

CAS#: 1635405-90-1 (racemic)

Description: 1D-2 is a highly potent and exquisitely selective inhibitor of the mesenchymal-epithelial transition factor (c-Met) protein kinase. Aberrant c-Met activation has been implicated in multiple tumor oncogenic processes and drug resistance.


Price and Availability

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1D-2 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561264
Name: 1D-2
CAS#: 1635405-90-1 (racemic)
Chemical Formula: C20H16FN7
Exact Mass: 373.1451
Molecular Weight: 373.4
Elemental Analysis: C, 64.33; H, 4.32; F, 5.09; N, 26.26


Synonym: 1D-2; 1D 2; 1D2

IUPAC/Chemical Name: (R)-7-fluoro-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]pyrazin-1-yl)ethyl)quinoline

InChi Key: SXWUXXWVCWEUTA-GFCCVEGCSA-N

InChi Code: InChI=1S/C20H16FN7/c1-12(15-6-13-4-3-5-22-17(13)7-16(15)21)28-11-24-19-20(28)26-18(9-23-19)14-8-25-27(2)10-14/h3-12H,1-2H3/t12-/m1/s1

SMILES Code: C[C@H](C1=C(F)C=C2N=CC=CC2=C1)N3C=NC4=NC=C(C5=CN(C)N=C5)N=C43


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Zhao F, Zhang J, Zhang L, Hao Y, Shi C, Xia G, Yu J, Liu Y. Discovery and optimization of a series of imidazo[4,5-b]pyrazine derivatives as highly potent and exquisitely selective inhibitors of the mesenchymal-epithelial transition factor (c-Met) protein kinase. Bioorg Med Chem. 2016 Sep 15;24(18):4281-90. doi: 10.1016/j.bmc.2016.07.019. Epub 2016 Jul 12. PubMed PMID: 27448775.