U-101958 Maleate

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MedKoo CAT#: 561155

CAS#: 224170-09-6

Description: U-101958 Maleate is a dopamine D4 receptor ligand. U-101958 Maleate also binds to a large sigma1 receptor-like component in human cerebellum and SK-N-MC neuroblastoma cells with high affinity.

Chemical Structure

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U-101958 Maleate
CAS# 224170-09-6
Instruction

Theoretical Analysis

MedKoo Cat#: 561155
Name: U-101958 Maleate
CAS#: 224170-09-6
Chemical Formula: C25H33N3O5
Exact Mass: 0.00
Molecular Weight: 455.560
Elemental Analysis: C, 65.91; H, 7.30; N, 9.22; O, 17.56

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: U-101958 Maleate, U 101958 Maleate, U101958 Maleate, U101958, U 101958, U-101958

IUPAC/Chemical Name: N-[1-Benzylpiperidin-4-yl]-N-methyl-3-propan-2-yloxypyridin-2-amine Maleate

InChi Key: KPYPLDPMBWPEBO-BTJKTKAUSA-N

InChi Code: InChI=1S/C21H29N3O.C4H4O4/c1-17(2)25-20-10-7-13-22-21(20)23(3)19-11-14-24(15-12-19)16-18-8-5-4-6-9-18;5-3(6)1-2-4(7)8/h4-10,13,17,19H,11-12,14-16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code: CC(OC1=CC=CN=C1N(C2CCN(CC3=CC=CC=C3)CC2)C)C.O=C(O)/C=C\C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 455.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gazi L, Bobirnac I, Danzeisen M, Schüpbach E, Langenegger D, Sommer B, Hoyer D, Tricklebank M, Schoeffter P. Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L-745,870 and U-101958 at human recombinant D4.4 receptors expressed in CHO cells. Br J Pharmacol. 1999 Oct;128(3):613-20. PubMed PMID: 10516640; PubMed Central PMCID: PMC1571689.

2: Helmeste DM, Shioiri T, Mitsuhashi M, Tang SW. Binding of [3H]U-101958 to sigma1 receptor-like sites in human cerebellum and neuroblastoma cells. Eur J Pharmacol. 1999 Apr 9;370(2):205-9. PubMed PMID: 10323271.

3: Gazi L, Bobirnac I, Danzeisen M, Schüpbach E, Bruinvels AT, Geisse S, Sommer B, Hoyer D, Tricklebank M, Schoeffter P. The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor. Br J Pharmacol. 1998 Jul;124(5):889-96. PubMed PMID: 9692773; PubMed Central PMCID: PMC1565470.