4-Fluoroamphetamine HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561073

CAS#: 64609-06-9

Description: 4-Fluoroamphetamine HCl, also known as 4-FA, 4-FMP or PAL-303, is a dopamine reuptake inhibitor. 4-Fluoroamphetamine HCl is a psychoactive research chemical of the phenethylamine and substituted amphetamine chemical classes. It produces stimulant and entactogenic effects.


Price and Availability

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4-Fluoroamphetamine HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561073
Name: 4-Fluoroamphetamine HCl
CAS#: 64609-06-9
Chemical Formula: C9H13ClFN
Exact Mass:
Molecular Weight: 189.66
Elemental Analysis: C, 57.00; H, 6.91; Cl, 18.69; F, 10.02; N, 7.39


Synonym: 4-Fluoroamphetamine HCl; 4 Fluoroamphetamine HCl; 4-FA; 4-FMP; PAL-303; 4 FA; 4 FMP; PAL 303; 4FA; 4FMP; PAL303

IUPAC/Chemical Name: 2-Amino-1-(4-fluorophenyl)propane Hydrochloride

InChi Key: GKWYMWZWSCKSMT-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H12FN.ClH/c1-7(11)6-8-2-4-9(10)5-3-8;/h2-5,7H,6,11H2,1H3;1H

SMILES Code: CC(N)CC1=CC=C(F)C=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

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2: Nugteren-van Lonkhuyzen JJ, van Riel AJ, Brunt TM, Hondebrink L. Pharmacokinetics, pharmacodynamics and toxicology of new psychoactive substances (NPS): 2C-B, 4-fluoroamphetamine and benzofurans. Drug Alcohol Depend. 2015 Dec 1;157:18-27. doi: 10.1016/j.drugalcdep.2015.10.011. Epub 2015 Oct 22. Review. Erratum in: Drug Alcohol Depend. 2016 Feb 1;159:287-8. PubMed PMID: 26530501.

3: Madias JE. Takotsubo syndrome due to 4-fluoroamphetamine. Clin Toxicol (Phila). 2015 Feb;53(2):136. doi: 10.3109/15563650.2014.998767. Epub 2015 Jan 20. PubMed PMID: 25600939.

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5: Fuller RW, Baker JC, Perry KW, Molloy BB. Comparison of 4-chloro-, 4-bromo- and 4-fluoroamphetamine in rats: drug levels in brain and effects on brain serotonin metabolism. Neuropharmacology. 1975 Oct;14(10):739-46. PubMed PMID: 1196472.

6: Poklis JL, Wolf CE, Poklis A. 4-Fluoroamphetamine in Serum and Urine from an Intoxicated Patient with Life-Threatening Hyperpyrexia. J Anal Toxicol. 2016 Mar;40(2):171-2. doi: 10.1093/jat/bkv139. Epub 2016 Jan 18. PubMed PMID: 26787750; PubMed Central PMCID: PMC4757635.

7: Rickli A, Hoener MC, Liechti ME. Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones. Eur Neuropsychopharmacol. 2015 Mar;25(3):365-76. doi: 10.1016/j.euroneuro.2014.12.012. Epub 2015 Jan 5. PubMed PMID: 25624004.

8: Marona-Lewicka D, Rhee GS, Sprague JE, Nichols DE. Psychostimulant-like effects of p-fluoroamphetamine in the rat. Eur J Pharmacol. 1995 Dec 12;287(2):105-13. PubMed PMID: 8749023.

9: Al-Abri S, Meier KH, Colby JM, Smollin CG, Benowitz NL. Cardiogenic shock after use of fluoroamphetamine confirmed with serum and urine levels. Clin Toxicol (Phila). 2014 Dec;52(10):1292-5. doi: 10.3109/15563650.2014.974262. Epub 2014 Oct 28. PubMed PMID: 25350468.

10: Plenevaux A, Dewey SL, Fowler JS, Guillaume M, Wolf AP. Synthesis of (R)-(-)- and (S)-(+)-4-fluorodeprenyl and (R)-(-)- and (S)-(+)-[N-11C-methyl]-4-fluorodeprenyl and positron emission tomography studies in baboon brain. J Med Chem. 1990 Jul;33(7):2015-9. PubMed PMID: 2113950.

11: Rust KY, Baumgartner MR, Dally AM, Kraemer T. Prevalence of new psychoactive substances: A retrospective study in hair. Drug Test Anal. 2012 Jun;4(6):402-8. doi: 10.1002/dta.1338. Epub 2012 Apr 22. PubMed PMID: 22522922.

12: Salomone A, Gazzilli G, Di Corcia D, Gerace E, Vincenti M. Determination of cathinones and other stimulant, psychedelic, and dissociative designer drugs in real hair samples. Anal Bioanal Chem. 2016 Mar;408(8):2035-42. doi: 10.1007/s00216-015-9247-4. Epub 2015 Dec 17. PubMed PMID: 26680593.

13: Wolf CE, Poklis JL, Cumpston K, Moss M, Poklis A. Acute dilated cardiomyopathy and myocardial injury after combined 4-fluoroamphetamine and modafinil ingestion. Drug Test Anal. 2017 Apr;9(4):657-659. doi: 10.1002/dta.1988. Epub 2016 May 30. PubMed PMID: 27238856.

14: Odoardi S, Romolo FS, Strano-Rossi S. A snapshot on NPS in Italy: Distribution of drugs in seized materials analysed in an Italian forensic laboratory in the period 2013-2015. Forensic Sci Int. 2016 Aug;265:116-20. doi: 10.1016/j.forsciint.2016.01.037. Epub 2016 Feb 1. PubMed PMID: 26874736.

15: Laskowski LK, Landry A, Vassallo SU, Hoffman RS. Ice water submersion for rapid cooling in severe drug-induced hyperthermia. Clin Toxicol (Phila). 2015 Mar;53(3):181-4. doi: 10.3109/15563650.2015.1009994. PubMed PMID: 25695144; PubMed Central PMCID: PMC4684641.

16: Johansen SS, Hansen TM. Isomers of fluoroamphetamines detected in forensic cases in Denmark. Int J Legal Med. 2012 Jul;126(4):541-7. doi: 10.1007/s00414-012-0671-0. PubMed PMID: 22286570.

17: Wijers CH, van Litsenburg RT, Hondebrink L, Niesink RJ, Croes EA. Acute toxic effects related to 4-fluoroamphetamine. Lancet. 2017 Feb 11;389(10069):600. doi: 10.1016/S0140-6736(17)30281-7. PubMed PMID: 28195054.

18: Holler JM, Vorce SP, Knittel JL, Malik-Wolf B, Levine B, Bosy TZ. Evaluation of designer amphetamine interference in GC-MS amine confirmation procedures. J Anal Toxicol. 2014 Jun;38(5):295-303. doi: 10.1093/jat/bku017. Epub 2014 Mar 30. PubMed PMID: 24687012.

19: McElroy JF, Miller JM, Meyer JS. Fenfluramine, p-chloroamphetamine and p-fluoroamphetamine stimulation of pituitary-adrenocortical activity in rat: evidence for differences in site and mechanism of action. J Pharmacol Exp Ther. 1984 Mar;228(3):593-9. PubMed PMID: 6323674.

20: Maas A, Wippich C, Madea B, Hess C. Driving under the influence of synthetic phenethylamines: a case series. Int J Legal Med. 2015 Sep;129(5):997-1003. doi: 10.1007/s00414-015-1150-1. Epub 2015 Jan 25. PubMed PMID: 25618172.