4-Fluorophenylalanine HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561070

CAS#: 122839-52-5 (HCl)

Description: 4-Fluorophenylalanine, also known as (S)-4-Fluorophenylalanine, L-4-Fluorophenylalanine and p-fluorophenylalanine, inhibits mitosis and reversible arrests HeLa cells in G2 phase.


Price and Availability

Size
Price

500mg
USD 450
Size
Price

1g
USD 750
Size
Price

4-Fluorophenylalanine HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561070
Name: 4-Fluorophenylalanine HCl
CAS#: 122839-52-5 (HCl)
Chemical Formula: C9H11ClFNO2
Exact Mass: 183.0696
Molecular Weight: 219.6404
Elemental Analysis: C, 49.22; H, 5.05; Cl, 16.14; F, 8.65; N, 6.38; O, 14.57


Related CAS #: 122839-52-5 (HCl)   51-65-0   1132-68-9; 122839-52-5  

Synonym: 4-Fluorophenylalanine; (S)-4-Fluorophenylalanine; L-4-Fluorophenylalanine; (S) 4 Fluorophenylalanine.

IUPAC/Chemical Name: (2S)-2-Amino-3-(4-fluorophenyl)propanoic acid hydrochloride

InChi Key: ZDECBCKSULAIGP-QRPNPIFTSA-N

InChi Code: InChI=1S/C9H10FNO2.ClH/c10-7-3-1-6(2-4-7)5-8(11)9(12)13;/h1-4,8H,5,11H2,(H,12,13);1H/t8-;/m0./s1

SMILES Code: O=C(O)[C@@H](N)CC1=CC=C(F)C=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Wheatley DN. Temperature and the progression of HeLa S-3 cells from G2 into mitosis in the presence and absence of the amino acid analogue, para-fluorophenylalanine. Cytobios. 1977;18(69):37-50. PubMed PMID: 608351.

2: Wheatley tdn, henderson JY. Recovery of HeLa cells from inhibited entry into mitosis induced by p-fluorophenylalanine. Exp Cell Res. 1975 Apr;92(1):211-20. PubMed PMID: 1132428.

3: Sunkara PS, Chakroborty BM, Wright DA, Rao PN. Chromosome condensing ability of mitotic proteins diminished by the substitution of phenylalanine with parafluorophenylalanine. Eur J Cell Biol. 1981 Feb;23(2):312-6. PubMed PMID: 7193581.

4: Rao PN, Sunkara PS. Correlation between the high rate of protein synthesis during mitosis and the absence of G1 period in V79-8 cells. Exp Cell Res. 1980 Feb;125(2):507-11. PubMed PMID: 7353608.

5: Inglis MS, Wheatley DN. Reversible retention of synchronized HeLa cells in G2 of the mammalian cell cycle. Cell Biol Int Rep. 1979 Dec;3(9):739-46. PubMed PMID: 509545.

6: Rao PN. The molecular basis of drug-induced G2 arrest in mammalian cells. Mol Cell Biochem. 1980 Jan 16;29(1):47-57. Review. PubMed PMID: 6154231.

7: Wheatley DN, Inglis MS. Amino acid analogues and the progression of HeLa cells into mitosis. I. Pre-mitotic arrest and thermosensitivity of HeLa cells in relation to the uptake and incorporation of various amino acid analogues. Exp Cell Res. 1977 Jun;107(1):191-9. PubMed PMID: 140806.

8: Brook JD, Chandley AC. Testing for the chemical induction of aneuploidy in the male mouse. Mutat Res. 1986 Apr;164(2):117-25. PubMed PMID: 3960041.

9: Parry JM, Sharp D, Parry EM. Detection of mitotic and meiotic aneuploidy in the yeast Saccharomyces cerevisiae. Environ Health Perspect. 1979 Aug;31:97-111. PubMed PMID: 387403; PubMed Central PMCID: PMC1637641.

10: Wheatley DN, Henderson JY. P-fluorophenylalanine and 'division-related proteins'. Nature. 1974 Feb 1;247(5439):281-3. PubMed PMID: 4818361.

11: Andersen O, Rønne M, Nordberg GF. Effects of inorganic metal salts on chromosome length in human lymphocytes. Hereditas. 1983;98(1):65-70. PubMed PMID: 6853219.

12: Babudri N, Morpurgo G. Frequency of spontaneous and induced recessive mutations in a diploid strain of Aspergillus nidulans. Mutat Res. 1990 Jun;230(2):187-95. PubMed PMID: 2197553.

13: Jouanneau JP. Protein synthesis requirement for the cytokinin effect upon tobacco cell division. Exp Cell Res. 1975 Mar 1;91(1):184-90. PubMed PMID: 1132416.

14: Andersen O, Rønne M. Effect of histidinol and parafluorophenylalanine on metaphase chromosome structure in human lymphoid cells. Hereditas. 1978;88(2):197-201. PubMed PMID: 689893.

15: Albertini S. Reevaluation of the 9 compounds reported conclusive positive in yeast Saccharomyces cerevisiae aneuploidy test systems by the Gene-Tox Program using strain D61.M of Saccharomyces cerevisiae. Mutat Res. 1991 Jun;260(2):165-80. PubMed PMID: 2046697.

16: Sisken JE, Wilkes E. The time of synthesis and the conservation of mitosis-related proteins in cultured human amnion cells. J Cell Biol. 1967 Jul;34(1):97-110. PubMed PMID: 6033548; PubMed Central PMCID: PMC2107237.

17: Singh M, Sinha U. Chloral hydrate induced haploidization in Aspergillus nidulans. Experientia. 1976 Sep 15;32(9):1144-5. PubMed PMID: 786720.