Dimethylamiloride hydrochloride
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MedKoo CAT#: 561030

CAS#: 2235-97-4 (HCl)

Description: Dimethylamiloride Hydrochloride is a Na(+)-H+ exchange inhibitor. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).


Chemical Structure

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Dimethylamiloride hydrochloride
CAS# 2235-97-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 561030
Name: Dimethylamiloride hydrochloride
CAS#: 2235-97-4 (HCl)
Chemical Formula: C8H13Cl2N7O
Exact Mass: 0.00
Molecular Weight: 294.140
Elemental Analysis: C, 32.67; H, 4.46; Cl, 24.10; N, 33.33; O, 5.44

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5mg USD 350 2 Weeks
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Related CAS #: 2235-97-4 (HCl)   1214-79-5 (free base)  

Synonym: 5-(N,N)-Dimethylamiloride Hydrochloride; 5-(N,N-dimethyl)-amiloride; DMA; 5-DMA; MK-685; L-591605;

IUPAC/Chemical Name: 3-Amino-6-chloro-N-(diaminomethylidene)-5-(dimethylamino)pyrazine-2-carboxamide;hydrochloride

InChi Key: IIUPTHVVXMBJMQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H

SMILES Code: O=C(C1=NC(Cl)=C(N(C)C)N=C1N)/N=C(N)\N.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 294.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Involvement of sodium in the protective effect of 5-(N,N-dimethyl)-amiloride on ischemia-reperfusion injury in isolated rat ventricular wall.
H Meng and G N Pierce
Journal of Pharmacology and Experimental Therapeutics March 1, 1991, 256 (3) 1094-1100;