VPC-13163

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561016

CAS#: 6637-10-1

Description: VPC-13163 has strong anti-proliferative activity against LNCaP and Enzalutamide-resistant prostate cancer cell lines (MR49F) whereas it did not affect the growth of AR independent PC3 cell line. It also inhibits Prostate Specific Antigen (PSA) in both LNCaP and MR49F and reduces expression of AR target genes, PSA and TMPRSS2. These findings suggest that VPC-13566 exhibits AR BF3 specific mechanism of action.


Chemical Structure

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VPC-13163
CAS# 6637-10-1

Theoretical Analysis

MedKoo Cat#: 561016
Name: VPC-13163
CAS#: 6637-10-1
Chemical Formula: C16H14N2
Exact Mass: 234.12
Molecular Weight: 234.300
Elemental Analysis: C, 82.02; H, 6.02; N, 11.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: VPC-13163, VPC 13163, VPC13163, NSC 52361, NSC52361, NSC52361

IUPAC/Chemical Name: 2,3-Dihydro-2,3'-bi-1H-indole

InChi Key: OGXXVLOAJZDVFY-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14N2/c1-3-7-14-11(5-1)9-16(18-14)13-10-17-15-8-4-2-6-12(13)15/h1-8,10,16-18H,9H2

SMILES Code: C1(C2=CNC3=C2C=CC=C3)NC4=C(C=CC=C4)C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 234.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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The development of anti-androgens with a new mechanism of action for treatment of resistant prostate cancer
Pharma Middle East
November 02-04, 2015 Dubai, UAE
Mohamed D H Hassona, Ravi Shashi Nayana Munuganti, Eric Leblanc, Fuqiang Ban, Paul S Rennie, Artem Cherkasov and Emma Guns
University of British Columbia, Canada
Posters-Accepted Abstracts: Clin Pharmacol Biopharm