FX1
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407501

CAS#: 1426138-42-2

Description: FX1 is an inhibitor of the B cell lymphoma 6 (BCL6). FX1 has 10-fold greater potency than endogenous corepressors and binds an essential region of the BCL6 lateral groove. FX1 disrupted formation of the BCL6 repression complex, reactivated BCL6 target genes, and mimicked the phenotype of mice engineered to express BCL6 with corepressor binding site mutations. Low doses of FX1 induced regression of established tumors in mice bearing DLBCL xenografts. Furthermore, FX1 suppressed ABC-DLBCL cells in vitro and in vivo, as well as primary human ABC-DLBCL specimens ex vivo.


Price and Availability

Size
Price

25mg
USD 150
200mg
USD 750
2g
USD 3450
Size
Price

50mg
USD 250
500mg
USD 1450
5g
USD 4950
Size
Price

100mg
USD 450
1g
USD 2250

FX1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 407501
Name: FX1
CAS#: 1426138-42-2
Chemical Formula: C14H9ClN2O4S2
Exact Mass: 367.969
Molecular Weight: 368.806
Elemental Analysis: C, 45.59; H, 2.46; Cl, 9.61; N, 7.60; O, 17.35; S, 17.39


Synonym: FX1; FX-1; FX 1.

IUPAC/Chemical Name: (5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid

InChi Key: VISHSGZPGQKEFX-KHPPLWFESA-N

InChi Code: InChI=1S/C14H9ClN2O4S2/c15-6-1-2-8-7(5-6)10(12(20)16-8)11-13(21)17(14(22)23-11)4-3-9(18)19/h1-2,5H,3-4H2,(H,16,20)(H,18,19)/b11-10-

SMILES Code: O=C(O)CCN(C/1=O)C(SC1=C2C(NC3=C/2C=C(Cl)C=C3)=O)=S


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Cardenas MG, Yu W, Beguelin W, Teater MR, Geng H, Goldstein RL, Oswald E,
Hatzi K, Yang SN, Cohen J, Shaknovich R, Vanommeslaeghe K, Cheng H, Liang D, Cho
HJ, Abbott J, Tam W, Du W, Leonard JP, Elemento O, Cerchietti L, Cierpicki T, Xue
F, MacKerell AD Jr, Melnick AM. Rationally designed BCL6 inhibitors target
activated B cell diffuse large B cell lymphoma. J Clin Invest. 2016 Sep
1;126(9):3351-62. doi: 10.1172/JCI85795. Epub 2016 Aug 2. PubMed PMID: 27482887;
PubMed Central PMCID: PMC5004937.