SU-1498
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407492

CAS#: 168835-82-3

Description: SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM).


Price and Availability

Size
Price

200mg
USD 1150
2g
USD 3450
Size
Price

500mg
USD 1750
5g
USD 5450
Size
Price

1g
USD 2250

SU 1498 is not in stock, is under synthesis and available by Early of July 2017. We accept order now.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407492
Name: SU-1498
CAS#: 168835-82-3
Chemical Formula: C25H30N2O2
Exact Mass: 390.2307
Molecular Weight: 390.527
Elemental Analysis: C, 76.89; H, 7.74; N, 7.17; O, 8.19


Synonym: SU-1498; SU 1498; SU1498; AG-1498; AG 1498; AG1498; Tyrphostin SU 1498

IUPAC/Chemical Name: (2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide

InChi Key: JANPYFTYAGTSIN-FYJGNVAPSA-N

InChi Code: InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+

SMILES Code: O=C(NCCCC1=CC=CC=C1)/C(C#N)=C/C2=CC(C(C)C)=C(O)C(C(C)C)=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Gawlak G, Son S, Tian Y, O'Donnell JJ 3rd, Birukov KG, Birukova AA. Chronic high-magnitude cyclic stretch stimulates EC inflammatory response via VEGF receptor 2-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1062-70. doi: 10.1152/ajplung.00317.2015. Epub 2016 Mar 18. PubMed PMID: 26993523; PubMed Central PMCID: PMC4935472.

2: Cai H, Xue Y, Li Z, Hu Y, Wang Z, Liu W, Li Z, Liu Y. Roundabout4 suppresses glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated PI3K/AKT and FAK signaling pathways. Cell Physiol Biochem. 2015;35(5):1689-705. doi: 10.1159/000373982. Epub 2015 Mar 18. PubMed PMID: 25833462.

3: Pan WK, Li P, Guo ZT, Huang Q, Gao Y. Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway. Pediatr Blood Cancer. 2015 Aug;62(8):1414-20. doi: 10.1002/pbc.25453. Epub 2015 Mar 1. PubMed PMID: 25728347.

4: Mesti T, Savarin P, Triba MN, Le Moyec L, Ocvirk J, Banissi C, Carpentier AF. Metabolic impact of anti-angiogenic agents on U87 glioma cells. PLoS One. 2014 Jun 12;9(6):e99198. doi: 10.1371/journal.pone.0099198. eCollection 2014. PubMed PMID: 24922514; PubMed Central PMCID: PMC4055646.

5: Kang Z, Zhu H, Luan H, Han F, Jiang W. Curculigoside A induces angiogenesis through VCAM-1/Egr-3/CREB/VEGF signaling pathway. Neuroscience. 2014 May 16;267:232-40. doi: 10.1016/j.neuroscience.2014.02.050. Epub 2014 Mar 12. Erratum in: Neuroscience. 2014 Sep 5;275:1. PubMed PMID: 24631678.

6: Kang Z, Zhu H, Jiang W, Zhang S. Protocatechuic acid induces angiogenesis through PI3K-Akt-eNOS-VEGF signalling pathway. Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):221-7. doi: 10.1111/bcpt.12094. Epub 2013 Jul 6. PubMed PMID: 23738793.

7: Kang Z, Jiang W, Luan H, Zhao F, Zhang S. Cornin induces angiogenesis through PI3K-Akt-eNOS-VEGF signaling pathway. Food Chem Toxicol. 2013 Aug;58:340-6. doi: 10.1016/j.fct.2013.05.017. Epub 2013 May 20. PubMed PMID: 23702325.

8: Kim EK, Kang SW, Kim JY, Min K, Kim TI. Modulation of bevacizumab-induced toxicity for cultured human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2013 Jun 6;54(6):3922-31. doi: 10.1167/iovs.12-11287. PubMed PMID: 23640039.

9: Pan Z, Fukuoka S, Karagianni N, Guaiquil VH, Rosenblatt MI. Vascular endothelial growth factor promotes anatomical and functional recovery of injured peripheral nerves in the avascular cornea. FASEB J. 2013 Jul;27(7):2756-67. doi: 10.1096/fj.12-225185. Epub 2013 Apr 8. PubMed PMID: 23568776; PubMed Central PMCID: PMC3688738.

10: Klettner A, Westhues D, Lassen J, Bartsch S, Roider J. Regulation of constitutive vascular endothelial growth factor secretion in retinal pigment epithelium/choroid organ cultures: p38, nuclear factor κB, and the vascular endothelial growth factor receptor-2/phosphatidylinositol 3 kinase pathway. Mol Vis. 2013;19:281-91. Epub 2013 Jan 3. PubMed PMID: 23401656; PubMed Central PMCID: PMC3566904.

11: Laird M, Woad KJ, Hunter MG, Mann GE, Robinson RS. Fibroblast growth factor 2 induces the precocious development of endothelial cell networks in bovine luteinising follicular cells. Reprod Fertil Dev. 2013;25(2):372-86. doi: 10.1071/RD12182. PubMed PMID: 23153420.

12: Hills CE, Younis MY, Bennett J, Siamantouras E, Liu KK, Squires PE. Calcium-sensing receptor activation increases cell-cell adhesion and β-cell function. Cell Physiol Biochem. 2012;30(3):575-86. doi: 10.1159/000341439. Epub 2012 Jul 25. PubMed PMID: 22832156.

13: Francescone R, Scully S, Bentley B, Yan W, Taylor SL, Oh D, Moral L, Shao R. Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 protein activation. J Biol Chem. 2012 Jul 13;287(29):24821-31. doi: 10.1074/jbc.M111.334540. Epub 2012 May 31. PubMed PMID: 22654102; PubMed Central PMCID: PMC3397909.

14: Kiuchi T, Lee H, Mikami T. Regular exercise cures depression-like behavior via VEGF-Flk-1 signaling in chronically stressed mice. Neuroscience. 2012 Apr 5;207:208-17. doi: 10.1016/j.neuroscience.2012.01.023. Epub 2012 Jan 20. PubMed PMID: 22306286.

15: Woad KJ, Hunter MG, Mann GE, Laird M, Hammond AJ, Robinson RS. Fibroblast growth factor 2 is a key determinant of vascular sprouting during bovine luteal angiogenesis. Reproduction. 2012 Jan 1;143(1):35-43. doi: 10.1530/REP-11-0277. Epub 2011 Oct 13. PubMed PMID: 21998077.

16: Hung HS, Chu MY, Lin CH, Wu CC, Hsu SH. Mediation of the migration of endothelial cells and fibroblasts on polyurethane nanocomposites by the activation of integrin-focal adhesion kinase signaling. J Biomed Mater Res A. 2012 Jan;100(1):26-37. doi: 10.1002/jbm.a.33224. Epub 2011 Oct 4. PubMed PMID: 21972215.

17: Ligęza J, Ligęza J, Klein A. Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells. Acta Biochim Pol. 2011;58(3):391-6. Epub 2011 Aug 29. PubMed PMID: 21887406.

18: Ferla R, Bonomi M, Otvos L Jr, Surmacz E. Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer. 2011 Jul 19;11:303. doi: 10.1186/1471-2407-11-303. PubMed PMID: 21771332; PubMed Central PMCID: PMC3146945.

19: Buharalioglu CK, Song CY, Yaghini FA, Ghafoor HU, Motiwala M, Adris T, Estes AM, Malik KU. Angiotensin II-induced process of angiogenesis is mediated by spleen tyrosine kinase via VEGF receptor-1 phosphorylation. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1043-55. doi: 10.1152/ajpheart.01018.2010. Epub 2011 Jun 3. PubMed PMID: 21642504; PubMed Central PMCID: PMC3191073.

20: Lu KT, Sun CL, Wo PY, Yen HH, Tang TH, Ng MC, Huang ML, Yang YL. Hippocampal neurogenesis after traumatic brain injury is mediated by vascular endothelial growth factor receptor-2 and the Raf/MEK/ERK cascade. J Neurotrauma. 2011 Mar;28(3):441-50. doi: 10.1089/neu.2010.1473. Epub 2011 Jan 9. PubMed PMID: 21091268.