2-DG
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526090

CAS#: 154-17-6

Description: 2-DG is an inhibitor of glycolysis via its actions on hexokinase, the rate limiting step of glycolysis.


Price and Availability

Size
Price

1g
USD 150
10g
USD 650
Size
Price

2g
USD 250
25g
USD 1050
Size
Price

5g
USD 450
50g
USD 1750

2-DG, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526090
Name: 2-DG
CAS#: 154-17-6
Chemical Formula: C6H12O5
Exact Mass: 164.0685
Molecular Weight: 164.157
Elemental Analysis: C, 43.90; H, 7.37; O, 48.73


Synonym: 2-DG

IUPAC/Chemical Name: 2-Deoxy-D-arabinohexose

InChi Key: VRYALKFFQXWPIH-PBXRRBTRSA-N

InChi Code: InChI=1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1

SMILES Code: O=CC[C@H]([C@@H]([C@@H](CO)O)O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

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2: Wang L, Dong Q, Zhu Q, Tang N, Jia S, Xi C, Zhao H, Han S, Wang Y. Conformational Characteristics of Rice Hexokinase OsHXK7 as a Moonlighting Protein involved in Sugar Signalling and Metabolism. Protein J. 2017 May 29. doi: 10.1007/s10930-017-9718-x. [Epub ahead of print] PubMed PMID: 28555318.

3: Ferreira GN, Rossi-Valentim R, Buzelle SL, Paula-Gomes S, Zanon NM, Garófalo MAR, Frasson D, Navegantes LCC, Chaves VE, Kettelhut IDC. Differential regulation of glyceroneogenesis by glucocorticoids in epididymal and retroperitoneal white adipose tissue from rats. Endocrine. 2017 May 29. doi: 10.1007/s12020-017-1315-4. [Epub ahead of print] PubMed PMID: 28555305.

4: Qian X, Xu W, Xu J, Shi Q, Li J, Weng Y, Jiang Z, Feng L, Wang X, Zhou J, Jin H. Enolase 1 stimulates glycolysis to promote chemoresistance in gastric cancer. Oncotarget. 2017 May 15. doi: 10.18632/oncotarget.17868. [Epub ahead of print] PubMed PMID: 28548950.

5: Mert I, Chhina J, Allo G, Dai J, Seward S, Carey MS, Llaurado M, Giri S, Rattan R, Munkarah AR. Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer. Gynecol Oncol. 2017 May 22. pii: S0090-8258(17)30871-5. doi: 10.1016/j.ygyno.2017.05.019. [Epub ahead of print] PubMed PMID: 28545687.

6: Svensson K, LaBarge SA, Martins VF, Schenk S. Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. Acta Physiol (Oxf). 2017 May 22. doi: 10.1111/apha.12897. [Epub ahead of print] PubMed PMID: 28544355.

7: Trask AE, Bignal EM, McCracken DI, Piertney SB, Reid JM. Estimating demographic contributions to effective population size in an age-structured wild population experiencing environmental and demographic stochasticity. J Anim Ecol. 2017 May 24. doi: 10.1111/1365-2656.12703. [Epub ahead of print] PubMed PMID: 28543048.

8: Tomasi DG, Shokri-Kojori E, Wiers CE, Kim SW, Demiral ŞB, Cabrera EA, Lindgren E, Miller G, Wang GJ, Volkow ND. Dynamic brain glucose metabolism identifies anti-correlated cortical-cerebellar networks at rest. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17708692. doi: 10.1177/0271678X17708692. [Epub ahead of print] PubMed PMID: 28534658.

9: Wang H, Arias EB, Yu CS, Verkerke ARP, Cartee GD. Effects of Calorie Restriction and Fiber Type on Glucose Uptake and Abundance of Electron Transport Chain and Oxidative Phosphorylation Proteins in Single Fibers from Old Rats. J Gerontol A Biol Sci Med Sci. 2017 May 22. doi: 10.1093/gerona/glx099. [Epub ahead of print] PubMed PMID: 28531280.

10: Foss CA, Liu L, Mease RC, Wang H, Pasricha P, Pomper MG. Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with [(125)I]iodoDPA SPECT-CT. J Nucl Med. 2017 May 18. pii: jnumed.117.189571. doi: 10.2967/jnumed.117.189571. [Epub ahead of print] PubMed PMID: 28522739.

11: Şimşek E, Şimşek T, Demiral M, Canaz F, Açıkalın MF. Bilateral painless testicular mass, acute uveitis and annular cutaneous lesions: an unusual presentation of sarcoidosis and literature review. J Clin Res Pediatr Endocrinol. 2017 May 17. doi: 10.4274/jcrpe.4350. [Epub ahead of print] PubMed PMID: 28515032.

12: Paldino MJ, Yang E, Jones JY, Mahmood N, Sher A, Zhang W, Hayatghaibi S, Krishnamurthy R, Seghers V. Comparison of the diagnostic accuracy of PET/MRI to PET/CT-acquired FDG brain exams for seizure focus detection: a prospective study. Pediatr Radiol. 2017 May 16. doi: 10.1007/s00247-017-3888-8. [Epub ahead of print] PubMed PMID: 28512714.

13: Yamada S, Ueki K, Kawai Y, Sako T, Shimomura Y, Tsuchimoto A, Tanaka S, Matsui R, Maeda H, Tokumoto M, Ooboshi H, Kitazono T, Tsuruya K. Extrapulmonary tuberculosis presented as fever of unknown origin in two patients with endstage kidney disease not on dialysis: usefulness of 18-FDG-PET/CT in the diagnostic localization of fever of unknown origin. CEN Case Rep. 2016 May;5(1):11-17. doi: 10.1007/s13730-015-0181-2. Epub 2015 Apr 21. PubMed PMID: 28509157; PubMed Central PMCID: PMC5411655.

14: Behjati M, Hashemi M, Kazemi M, Salehi M, Javanmard SH. Evaluation of Energy Balance on Human Telomerase Reverse Transcriptase (hTERT) Alternative Splicing by Semi-quantitative RT-PCR in Human Umbilical Vein Endothelial Cells. Adv Biomed Res. 2017 Apr 17;6:43. doi: 10.4103/2277-9175.204591. eCollection 2017. PubMed PMID: 28503498; PubMed Central PMCID: PMC5414409.

15: Ginat DT, Westiin C, Brisson RJ, Chin CT, Pu Y, Zhang H, De Souza JA. Pilot Study of 99mTc-labeled Ethylene Dicysteine Deoxyglucose SPECT-CT Imaging in Treatment Response Evaluation in Patients with Locally Advanced Head and Neck Cancer. Cureus. 2017 Apr 11;9(4):e1152. doi: 10.7759/cureus.1152. PubMed PMID: 28503388; PubMed Central PMCID: PMC5426824.

16: Lai JP, Yue Y, Zhang W, Zhou Y, Frishberg D, Jamil LH, Mirocha JM, Guindi M, Balzer B, Bose S, Cao D, Lo S, Fan X, Rutgers JK. Comparison of endoscopic ultrasound guided fine needle aspiration and PET/CT in preoperative diagnosis of pancreatic adenocarcinoma. Pancreatology. 2017 Apr 13. pii: S1424-3903(17)30074-1. doi: 10.1016/j.pan.2017.04.008. [Epub ahead of print] PubMed PMID: 28501471.

17: Torres-Cuevas I, Aupi M, Asensi MA, Vento M, Ortega Á, Escobar J. 7,8-hydroxy-2'-deoxyguanosine/2'-deoxiguanosine ratio determined in hydrolysates of brain DNA by ultrachromatrography coupled to tandem mass spectrometry. Talanta. 2017 Aug 1;170:97-102. doi: 10.1016/j.talanta.2017.03.072. Epub 2017 Mar 28. PubMed PMID: 28501220.

18: Villar PS, Delgado R, Vergara C, Reyes JG, Bacigalupo J. Energy requirements of odor transduction in the chemosensory cilia of olfactory sensory neurons rely on oxidative phosphorylation and glycolytic processing of extracellular glucose. J Neurosci. 2017 May 12. pii: 2640-16. doi: 10.1523/JNEUROSCI.2640-16.2017. [Epub ahead of print] PubMed PMID: 28500222.

19: Sun C, Du W, Wang B, Yao Z, Liu J, Wang J, Xie W, Wu T, Fan Y, Yang H. Synthesis of a new deoxyglucose derivative modified near-infrared fluorescent probe for tumor diagnosis. Biochem Biophys Res Commun. 2017 Jun 24;488(2):340-347. doi: 10.1016/j.bbrc.2017.05.046. Epub 2017 May 9. PubMed PMID: 28499871.

20: Armstrong IS, Tonge CM, Arumugam P. Assessing time-of-flight signal-to-noise ratio gains within the myocardium and subsequent reductions in administered activity in cardiac PET studies. J Nucl Cardiol. 2017 May 11. doi: 10.1007/s12350-017-0916-x. [Epub ahead of print] PubMed PMID: 28497418.