CFMTI
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525385

CAS#: 864864-17-5

Description: CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist


Price and Availability

Size
Price

100mg
USD 1350
1g
USD 3450
Size
Price

200mg
USD 1950
2g
USD 5250
Size
Price

500mg
USD 2650
5g
Ask price

CFMTI, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525385
Name: CFMTI
CAS#: 864864-17-5
Chemical Formula: C19H16FN5O
Exact Mass: 349.1339
Molecular Weight: 349.3694
Elemental Analysis: C, 65.32; H, 4.62; F, 5.44; N, 20.05; O, 4.58


Synonym: CFMTI

IUPAC/Chemical Name: 2-Cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one

InChi Key: XZBFQWRAIYRPPZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H16FN5O/c1-11-17(22-23-25(11)16-3-2-8-21-18(16)20)12-4-7-15-13(9-12)10-24(19(15)26)14-5-6-14/h2-4,7-9,14H,5-6,10H2,1H3

SMILES Code: O=C1N(C2CC2)CC3=C1C=CC(C4=C(C)N(C5=CC=CN=C5F)N=N4)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Suzuki G, Satow A, Ohta H. Effect of CFMTI, an allosteric metabotropic glutamate receptor 1 antagonist with antipsychotic activity, on Fos expression in regions of the brain related to schizophrenia. Neuroscience. 2010 Jul 14;168(3):787-96. doi: 10.1016/j.neuroscience.2010.04.016. Epub 2010 Apr 18. PubMed PMID: 20399255.

2: Hikichi H, Nishino M, Fukushima M, Satow A, Maehara S, Kawamoto H, Ohta H. Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice. Eur J Pharmacol. 2010 Aug 10;639(1-3):99-105. doi: 10.1016/j.ejphar.2010.03.046. Epub 2010 Apr 2. PubMed PMID: 20371235.

3: Satow A, Suzuki G, Maehara S, Hikichi H, Murai T, Murai T, Kawagoe-Takaki H, Hata M, Ito S, Ozaki S, Kawamoto H, Ohta H. Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dih ydro-1H-isoindol-1-one. J Pharmacol Exp Ther. 2009 Jul;330(1):179-90. doi: 10.1124/jpet.109.151118. Epub 2009 Apr 9. PubMed PMID: 19359526.