SAR-20347
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407471

CAS#: 1450881-55-6

Description: SAR-20347 is a potent dual inhibitor of JAK1 and tyrosine kinase 2 (TYK2). SAR-20347 dose dependently (1 nM-10 μM) inhibited JAK1- and/or TYK2-dependent signaling from the IL-12/IL-23, IL-22, and IFN-α receptors. In vivo, TYK2 mutant mice or treatment of wild-type mice with SAR-20347 significantly reduced IL-12-induced IFN-γ production and IL-22-dependent serum amyloid A to similar extents, indicating that, in these models.


Price and Availability

Size
Price

10mg
USD 190
Size
Price

25mg
USD 350
Size
Price

50mg
USD 650

SAR-20347, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 407471
Name: SAR-20347
CAS#: 1450881-55-6
Chemical Formula: C21H18ClFN4O4
Exact Mass: 444.1001
Molecular Weight: 444.8474
Elemental Analysis: C, 56.70; H, 4.08; Cl, 7.97; F, 4.27; N, 12.59; O, 14.39


Synonym: SAR-20347; SAR 20347; SAR20347.

IUPAC/Chemical Name: 2-(2-Chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-4-oxazolecarboxamide

InChi Key: HEDPDFHTQKEORT-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H18ClFN4O4/c22-14-2-1-3-15(23)16(14)19-26-17(18(24)28)20(31-19)25-13-6-4-12(5-7-13)21(29)27-8-10-30-11-9-27/h1-7,25H,8-11H2,(H2,24,28)

SMILES Code: O=C(C1=C(NC2=CC=C(C(N3CCOCC3)=O)C=C2)OC(C4=C(F)C=CC=C4Cl)=N1)N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Works MG, Yin F, Yin CC, Yiu Y, Shew K, Tran TT, Dunlap N, Lam J, Mitchell T,
Reader J, Stein PL, D'Andrea A. Inhibition of TYK2 and JAK1 ameliorates
imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the
IL-23/IL-17 axis. J Immunol. 2014 Oct 1;193(7):3278-87. doi:
10.4049/jimmunol.1400205. Epub 2014 Aug 25. PubMed PMID: 25156366; PubMed Central
PMCID: PMC4170002.