ZINC-3573
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MedKoo CAT#: 530612

CAS#: 2089389-15-9

Description: ZINC-3573 is a potent and highly selective MRGPRX2 probe. The MRGPRX2-activating opioids and ZINC-3573 induced intracellular Ca2+ release and degranulation in a human mast cell line. ZINC-3573 activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release. MRGPRX2 is a unique atypical opioid-like receptor important for modulating mast cell degranulation, which can now be specifically modulated with ZINC-3573.

Chemical Structure

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ZINC-3573
CAS# 2089389-15-9
Instruction

Theoretical Analysis

MedKoo Cat#: 530612
Name: ZINC-3573
CAS#: 2089389-15-9
Chemical Formula: C18H21N5
Exact Mass: 307.18
Molecular Weight: 307.401
Elemental Analysis: C, 70.33; H, 6.89; N, 22.78

Price and Availability

Size Price Availability Quantity
25mg USD 450 2 Weeks
50mg USD 750 2 Weeks
100mg USD 1250 2 Weeks
200mg USD 1950 2 Weeks
500mg USD 2950 2 Weeks
1g USD 4650 2 Weeks
2g USD 6450 2 Weeks
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Related CAS #: 2089389-15-9 (R-isomer)   1378183-16-4 (racemic mixture)    

Synonym: ZINC-3573; ZINC 3573; ZINC3573.

IUPAC/Chemical Name: (R)-Dimethyl-[1-(5-phenyl-pyrazolo[1,5-a]pyrimidin-7-yl)-pyrrolidin-3-yl]-amine

InChi Key: XKBSPAZCFAIBJL-OAHLLOKOSA-N

InChi Code: InChI=1S/C18H21N5/c1-21(2)15-9-11-22(13-15)18-12-16(14-6-4-3-5-7-14)20-17-8-10-19-23(17)18/h3-8,10,12,15H,9,11,13H2,1-2H3/t15-/m1/s1

SMILES Code: CN(C)[C@H]1CN(C2=CC(C3=CC=CC=C3)=NC4=CC=NN24)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 307.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H,
Carroll FI, Jin J, Shoichet BK, Roth BL. In silico design of novel probes for the
atypical opioid receptor MRGPRX2. Nat Chem Biol. 2017 May;13(5):529-536. doi:
10.1038/nchembio.2334. Epub 2017 Mar 13. PubMed PMID: 28288109; PubMed Central
PMCID: PMC5391270.