ML311
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MedKoo CAT#: 407459

CAS#: 315698-17-0

Description: ML311, also known as EU-5346, is a potent and selective inhibitor of the Protein-Protein Interaction of Mcl-1 and Bim. ML311 Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim. EU-5346 will be a useful tool for studying lymphoid tumorigenesis and to demonstrate the potential for using this strategy in therapies intended to bypass apoptosis resistance pathways that are activated in drug-resistant tumors.


Price and Availability

Size
Price

100mg
USD 1250
1g
USD 3250
Size
Price

200mg
USD 1950
2g
USD 4950
Size
Price

500mg
USD 2450
5g
USD 6450

ML311, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407459
Name: ML311
CAS#: 315698-17-0
Chemical Formula: C23H24F3N3O
Exact Mass: 415.1871
Molecular Weight: 415.4602
Elemental Analysis: C, 66.49; H, 5.82; F, 13.72; N, 10.11; O, 3.85


Synonym: ML311; ML-311; ML 311; EU-5346; EU 5346; EU5346.

IUPAC/Chemical Name: 7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol

InChi Key: NGAPBLRRJSKIRT-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H24F3N3O/c1-2-28-12-14-29(15-13-28)21(17-5-8-18(9-6-17)23(24,25)26)19-10-7-16-4-3-11-27-20(16)22(19)30/h3-11,21,30H,2,12-15H2,1H3

SMILES Code: OC1=C2N=CC=CC2=CC=C1C(N3CCN(CC)CC3)C4=CC=C(C(F)(F)F)C=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bannister T, Koenig M, He Y, Mishra J, Spicer T, Minond D, Saldanha A, Mercer
BA, Cameron M, Lena R, Carlson N, Richard D, Cardone M, Hodder P. ML311: A Small
Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction
of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. 2012 Apr 16
[updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program
[Internet]. Bethesda (MD): National Center for Biotechnology Information (US);
2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK143557/
PubMed PMID: 23762927.