EBE-A22
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MedKoo CAT#: 407458

CAS#: 229476-53-3

Description: EBE-A22 is a derivative of PD 153035. EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. EBE-A22 binds to DNA and behave as typical intercalating agents. EBE-A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE-A22, but not PD153035, interacts preferentially with GC-rich sequences and discriminates against homooligomeric runs of A and T which are often cut more readily by the enzyme in the presence of the drug compared to the control.


Price and Availability

Size
Price

100mg
USD 950
1g
USD 3250
Size
Price

200mg
USD 1650
2g
USD 4950
Size
Price

500mg
USD 2150
5g
USD 6750

EBE-A22, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407458
Name: EBE-A22
CAS#: 229476-53-3
Chemical Formula: C17H16BrN3O2
Exact Mass: 373.0426
Molecular Weight: 374.238
Elemental Analysis: C, 54.56; H, 4.31; Br, 21.35; N, 11.23; O, 8.55


Synonym: EBE-A22; EBE A22; EBEA22.

IUPAC/Chemical Name: N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine

InChi Key: IPWGDOZPSOZFOD-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H16BrN3O2/c1-21(12-6-4-5-11(18)7-12)17-13-8-15(22-2)16(23-3)9-14(13)19-10-20-17/h4-10H,1-3H3

SMILES Code: CN(C1=CC=CC(Br)=C1)C2=C3C=C(OC)C(OC)=CC3=NC=N2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

PD153035 exhibits a very high affinity and selectivity for the epidermal growth factor receptor tyrosine kinase (EGF-R TK) and shows a remarkable cytotoxicity against several types of tumor cell lines.


References

1: Goossens JF, Bouey-Bencteux E, Houssin R, Hénichart JP, Colson P, Houssier C,
Laine W, Baldeyrou B, Bailly C. DNA interaction of the tyrosine protein kinase
inhibitor PD153035 and its N-methyl analogue. Biochemistry. 2001 Apr
17;40(15):4663-71. PubMed PMID: 11294633.

2: Grunt TW, Tomek K, Wagner R, Puckmair K, Kainz B, Rünzler D, Gaiger A, Köhler
G, Zielinski CC. Upregulation of retinoic acid receptor-beta by the epidermal
growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB
pathways. J Cell Physiol. 2007 Jun;211(3):803-15. PubMed PMID: 17286282.