MDK35833
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407454

CAS#: 1016535-83-3

Description: MDK35833, also known as Oct3/4-inducer-1, is a potent Oct3/4-inducer. MDK35833 can promot expression and stabilization of Oct3/4 and enhance its transcriptional activity in diverse human somatic cells, implying the possible benefit from using this class of compounds in regenerative medicine.


Price and Availability

Size
Price

1g
USD 2950
Size
Price

2g
USD 4250
Size
Price

5g
USD 7650

MDK35833 or Oct3/4-inducer-1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 407454
Name: MDK35833
CAS#: 1016535-83-3
Chemical Formula: C15H12FNO
Exact Mass: 241.0903
Molecular Weight: 241.2654
Elemental Analysis: C, 74.68; H, 5.01; F, 7.87; N, 5.81; O, 6.63


Synonym: Oct3/4-inducer-1, MDK35833; MDK-35833; MDK 35833.

IUPAC/Chemical Name: 4-[(4-Fluorophenyl)methoxy]-benzeneacetonitrile

InChi Key: PXFUNIXWNXRVEJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H12FNO/c16-14-5-1-13(2-6-14)11-18-15-7-3-12(4-8-15)9-10-17/h1-8H,9,11H2

SMILES Code: N#CCC1=CC=C(OCC2=CC=C(F)C=C2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

CBP (CREB (cAMP responsive element binding protein) binding protein (CREBBP)) and P300 (adenovirus E1A-associated 300 kDa protein) are two closely related histone acetyltransferases (HATs) that play a key role in the regulation of gene transcription. Both proteins contain a bromodomain flanking the HAT catalytic domain that is important for the targeting of CBP/P300 to chromatin and which offeres an opportunity for the development of protein-protein interaction inhibitors.


References

1: Popp TA, Tallant C, Rogers C, Fedorov O, Brennan PE, Müller S, Knapp S,
Bracher F. Development of Selective CBP/P300 Benzoxazepine Bromodomain
Inhibitors. J Med Chem. 2016 Oct 13;59(19):8889-8912. Epub 2016 Sep 27. PubMed
PMID: 27673482.