MDK35833
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MedKoo CAT#: 407454

CAS#: 1016535-83-3

Description: MDK35833, also known as Oct3/4-inducer-1, is a potent Oct3/4-inducer. MDK35833 can promot expression and stabilization of Oct3/4 and enhance its transcriptional activity in diverse human somatic cells, implying the possible benefit from using this class of compounds in regenerative medicine.

Chemical Structure

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MDK35833
CAS# 1016535-83-3
Instruction

Theoretical Analysis

MedKoo Cat#: 407454
Name: MDK35833
CAS#: 1016535-83-3
Chemical Formula: C15H12FNO
Exact Mass: 241.09
Molecular Weight: 241.265
Elemental Analysis: C, 74.68; H, 5.01; F, 7.87; N, 5.81; O, 6.63

Price and Availability

Size Price Availability Quantity
100mg USD 250 2 Weeks
250mg USD 525 2 Weeks
500mg USD 850 2 Weeks
1g USD 1350 2 Weeks
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Synonym: Oct3/4-inducer-1, MDK35833; MDK-35833; MDK 35833.

IUPAC/Chemical Name: 4-[(4-Fluorophenyl)methoxy]-benzeneacetonitrile

InChi Key: PXFUNIXWNXRVEJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H12FNO/c16-14-5-1-13(2-6-14)11-18-15-7-3-12(4-8-15)9-10-17/h1-8H,9,11H2

SMILES Code: N#CCC1=CC=C(OCC2=CC=C(F)C=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: CBP (CREB (cAMP responsive element binding protein) binding protein (CREBBP)) and P300 (adenovirus E1A-associated 300 kDa protein) are two closely related histone acetyltransferases (HATs) that play a key role in the regulation of gene transcription. Both proteins contain a bromodomain flanking the HAT catalytic domain that is important for the targeting of CBP/P300 to chromatin and which offeres an opportunity for the development of protein-protein interaction inhibitors.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 241.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Popp TA, Tallant C, Rogers C, Fedorov O, Brennan PE, Müller S, Knapp S,
Bracher F. Development of Selective CBP/P300 Benzoxazepine Bromodomain
Inhibitors. J Med Chem. 2016 Oct 13;59(19):8889-8912. Epub 2016 Sep 27. PubMed
PMID: 27673482.